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==Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with IDI-6273==
==Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with IDI-6273==
<StructureSection load='4cqa' size='340' side='right' caption='[[4cqa]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
<StructureSection load='4cqa' size='340' side='right'caption='[[4cqa]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4cqa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CQA FirstGlance]. <br>
<table><tr><td colspan='2'>[[4cqa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CQA FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ID6:2-(4-CHLOROBENZYL)-8-ETHOXY-1,3-DIMETHYLCYCLOHEPTA[C]PYRROL-4(2H)-ONE'>ID6</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.82&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cq8|4cq8]], [[4cq9|4cq9]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ID6:2-(4-CHLOROBENZYL)-8-ETHOXY-1,3-DIMETHYLCYCLOHEPTA[C]PYRROL-4(2H)-ONE'>ID6</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cqa OCA], [https://pdbe.org/4cqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cqa RCSB], [https://www.ebi.ac.uk/pdbsum/4cqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cqa ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cqa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cqa RCSB], [http://www.ebi.ac.uk/pdbsum/4cqa PDBsum]</span></td></tr>
</table>
<table>
== Function ==
[https://www.uniprot.org/uniprot/PYRD_PLAF7 PYRD_PLAF7] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4cqa" style="background-color:#fffaf0;"></div>
==See Also==
*[[Dihydroorotate dehydrogenase 3D structures|Dihydroorotate dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Plafa]]
[[Category: Large Structures]]
[[Category: Rowland, P.]]
[[Category: Plasmodium falciparum]]
[[Category: Dhodh]]
[[Category: Rowland P]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/4cqa"