4u9m: Difference between revisions
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New page: '''Unreleased structure''' The entry 4u9m is ON HOLD Authors: Acosta-Reyes, F.J., Alechaga, E., Subirana, J.A., Campos, J.L. Description: Structure of the DNA duplex d(ATTAAT)2 with Ho... |
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The | ==Structure of the DNA duplex d(ATTAAT)2 with Hoogsteen hydrogen bonds== | ||
<StructureSection load='4u9m' size='340' side='right'caption='[[4u9m]], [[Resolution|resolution]] 3.13Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4u9m]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U9M FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.13Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u9m OCA], [https://pdbe.org/4u9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u9m RCSB], [https://www.ebi.ac.uk/pdbsum/4u9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u9m ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The traditional Watson-Crick base pairs in DNA may occasionally adopt a Hoogsteen conformation, with a different organization of hydrogen bonds. Previous crystal structures have shown that the Hoogsteen conformation is favored in alternating AT sequences of DNA. Here we present new data for a different sequence, d(ATTAAT)2, which is also found in the Hoogsteen conformation. Thus we demonstrate that other all-AT sequences of DNA with a different sequence may be found in the Hoogsteen conformation. We conclude that any all-AT sequence might acquire this conformation under appropriate conditions. We also compare the detailed features of DNA in either the Hoogsteen or Watson-Crick conformations. | |||
Structure of the DNA Duplex d(ATTAAT)2 with Hoogsteen Hydrogen Bonds.,Acosta-Reyes FJ, Alechaga E, Subirana JA, Campos JL PLoS One. 2015 Mar 17;10(3):e0120241. doi: 10.1371/journal.pone.0120241., eCollection 2015. PMID:25781995<ref>PMID:25781995</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4u9m" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Acosta-Reyes FJ]] | |||
[[Category: Alechaga E]] | |||
[[Category: Campos JL]] | |||
[[Category: Subirana JA]] | |||
Latest revision as of 12:27, 20 December 2023
Structure of the DNA duplex d(ATTAAT)2 with Hoogsteen hydrogen bonds
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