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[[Image:1dlp.gif|left|200px]]


{{Structure
==STRUCTURAL CHARACTERIZATION OF THE NATIVE FETUIN-BINDING PROTEIN SCILLA CAMPANULATA AGGLUTININ (SCAFET): A NOVEL TWO-DOMAIN LECTIN==
|PDB= 1dlp |SIZE=350|CAPTION= <scene name='initialview01'>1dlp</scene>, resolution 3.3&Aring;
<StructureSection load='1dlp' size='340' side='right'caption='[[1dlp]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1dlp]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hyacinthoides_hispanica Hyacinthoides hispanica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DLP FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dlp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dlp OCA], [https://pdbe.org/1dlp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dlp RCSB], [https://www.ebi.ac.uk/pdbsum/1dlp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dlp ProSAT]</span></td></tr>
}}
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9ZP48_HYAHI Q9ZP48_HYAHI]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/1dlp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dlp ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The three-dimensional structure of a 244-residue, multivalent, fetuin-binding lectin, SCAfet, isolated from bluebell (Scilla campanulata) bulbs, has been solved at 3.3 A resolution by molecular replacement using the coordinates of the 119-residue, mannose-binding lectin, SCAman, also from bluebell bulbs. Unlike most monocot mannose-binding lectins, such as Galanthus nivalis agglutinin from snowdrop bulbs, which fold into a single domain, SCAfet contains two domains with approximately 55% sequence identity, joined by a linker peptide. Both domains are made up of a 12-stranded beta-prism II fold, with three putative carbohydrate-binding sites, one on each subdomain. SCAfet binds to the complex saccharides of various animal glycoproteins but not to simple sugars.


'''STRUCTURAL CHARACTERIZATION OF THE NATIVE FETUIN-BINDING PROTEIN SCILLA CAMPANULATA AGGLUTININ (SCAFET): A NOVEL TWO-DOMAIN LECTIN'''
Structural characterisation of the native fetuin-binding protein Scilla campanulata agglutinin: a novel two-domain lectin.,Wright LM, Reynolds CD, Rizkallah PJ, Allen AK, Van Damme EJ, Donovan MJ, Peumans WJ FEBS Lett. 2000 Feb 18;468(1):19-22. PMID:10683433<ref>PMID:10683433</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1dlp" style="background-color:#fffaf0;"></div>


==Overview==
==See Also==
The three-dimensional structure of a 244-residue, multivalent, fetuin-binding lectin, SCAfet, isolated from bluebell (Scilla campanulata) bulbs, has been solved at 3.3 A resolution by molecular replacement using the coordinates of the 119-residue, mannose-binding lectin, SCAman, also from bluebell bulbs. Unlike most monocot mannose-binding lectins, such as Galanthus nivalis agglutinin from snowdrop bulbs, which fold into a single domain, SCAfet contains two domains with approximately 55% sequence identity, joined by a linker peptide. Both domains are made up of a 12-stranded beta-prism II fold, with three putative carbohydrate-binding sites, one on each subdomain. SCAfet binds to the complex saccharides of various animal glycoproteins but not to simple sugars.
*[[Agglutinin 3D structures|Agglutinin 3D structures]]
 
== References ==
==About this Structure==
<references/>
1DLP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hyacinthoides_hispanica Hyacinthoides hispanica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLP OCA].
__TOC__
 
</StructureSection>
==Reference==
Structural characterisation of the native fetuin-binding protein Scilla campanulata agglutinin: a novel two-domain lectin., Wright LM, Reynolds CD, Rizkallah PJ, Allen AK, Van Damme EJ, Donovan MJ, Peumans WJ, FEBS Lett. 2000 Feb 18;468(1):19-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10683433 10683433]
[[Category: Hyacinthoides hispanica]]
[[Category: Hyacinthoides hispanica]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Allen, A K.]]
[[Category: Allen AK]]
[[Category: Donovan, M J.]]
[[Category: Donovan MJ]]
[[Category: Peumans, W J.]]
[[Category: Peumans WJ]]
[[Category: Reynolds, C D.]]
[[Category: Reynolds CD]]
[[Category: Rizkallah, P J.]]
[[Category: Rizkallah PJ]]
[[Category: VanDamme, E J.M.]]
[[Category: VanDamme EJM]]
[[Category: Wright, L M.]]
[[Category: Wright LM]]
[[Category: beta prism ii fold]]
[[Category: native]]
[[Category: two-domain lectin]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:40:27 2008''
Retrieved from "https://proteopedia.org/1dlp"