Geranylgeranyl transferase: Difference between revisions

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<StructureSection load='3dst' size='340' side='right' caption='Structure of rat geranylgeranyl transferase type 2 subunits α (grey) and β (green) complex with geranylgeranyl pyrophosphate, Zn+2 (grey) and Ca+2 (green) ions(PDB code [[3dst]]).' scene=''>
<StructureSection load='3dst' size='350' side='right' caption='Structure of rat geranylgeranyl transferase type 2 subunits α (magenta) and β (cyan) complex with geranylgeranyl pyrophosphate, Zn+2 (grey) and Ca+2 (green) ions (PDB code [[3dst]]).' scene='59/597443/Cv/1'>


== Function ==
== Function ==


'''Geranylgeranyl transferase''' type 1 (GGT1) adds a 20-carbon isoprenoid group called geranylgeranyl (GG) to the C-terminal of proteins containg the CAAX motif (Cysteine, Aliphatic, Aliphatic, any amino acid).  Geranylgeranyl transferase type 2 (GGT2) adds 2 GG groups to C-terminal cysteine residue of a protein.  The addition of the hydrophobic prenyl group causes the proteins to become membrane-associated.  
'''Geranylgeranyl transferase''' '''type 1''' (GGT1) adds a 20-carbon isoprenoid group called geranylgeranyl (GG) to the C-terminal of proteins containing the CAAX motif (Cysteine, Aliphatic, Aliphatic, any amino acid).  '''Geranylgeranyl transferase type 2''' (GGT2) adds 2 GG groups to C-terminal cysteine residue of a protein.  The addition of the hydrophobic prenyl group causes the proteins to become membrane-associated<ref>PMID:16477080</ref>.  


== Disease ==
== Relevance ==


== Relevance ==
GGT2 inhibitors block bone resorption and induces myeloma cell apoptosis<ref>PMID:18929536</ref>.


== Structural highlights ==
== Structural highlights ==


==3D structures of eranylgeranyl transferase==
The <scene name='59/597443/Cv/5'>active site with bound geranylgeranyl pyrophosphate</scene> contains a <scene name='59/597443/Cv/6'>Zn+2 atom</scene><ref>PMID:18756270</ref>. Water molecules shown as red spheres.
 
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
===Geranylgeranyl transferase type 1===
 
[[1s64]] – rGGT1  α+β subunits + inhibitor - rat<br />
[[1n4p]] – rGGT1 α+β subunits + GGPP<br />
[[1n4s]], [[1n4r]] – rGGT1 α+β subunits + GGPP + peptide-GG containing CAAX <br />
[[1tnb]], [[1tno]], [[1tnu]], [[1tny]], [[1tnz]], [[1n4q]] – rGGT1 α+β subunits + GGPP analog + peptide containing CAAX<br />
[[3dra]] – GGT1 α+β subunits + GGPP – ''Candida albicans''<br />
 
===Geranylgeranyl transferase type 2===
 
[[1dce]] – rGGT2 α+β subunits – rat<br />
[[3dss]] – rGGT2 α+β subunits <br />


''Geranylgeranyl transferase type 2 complex''
==3D structures of geranylgeranyl transferase==
[[Geranylgeranyl transferase 3D structures]]


[[3c72]], [[3pz1]], [[3pz3]], [[4ehm]], [[4gts]], [[4gtt]], [[4gtv]] – rGGT2 α+β subunits + inhibitor<br />
</StructureSection>
[[3hxb]], [[3hxc]], [[3hxd]], [[3hxe]], [[3hxf]] – rGGT2 α (mutant) +β subunits + inhibitor<br />
[[1ltx]] – rGGT α+β subunits + tetra-alanine + Rab escort protein + farnesyl<br />
[[3dst]] – rGGT2 α+β subunits + GGPP<br />
[[3dsu]] – rGGT2 α+β subunits + farnesyl-PP<br />
[[3dsv]], [[3dsw]], [[3dsx]] – rGGT2 α+β subunits + GG<br />
[[3pz2]] – rGGT2 α+β subunits + GGPP + inhibitor<br />


== References ==
== References ==

Latest revision as of 09:12, 25 June 2024

Structure of rat geranylgeranyl transferase type 2 subunitsα (magenta) and β (cyan) complex with geranylgeranyl pyrophosphate, Zn+2 (grey) and Ca+2 (green) ions (PDB code 3dst).

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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