CD47: Difference between revisions
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<StructureSection load='' size='350' side='right' scene='53/538855/Cv/1' caption='Glycosylated human CD47 residues 19-136 (mutant) (green) complex with SIRP α (cyan) and I- ions [[2jjs]]'> | |||
__TOC__ | |||
== Function == | |||
'''CD47 (Cluster of Differentiation 47)''' is a protein which is expressed by cancer cells to avoid detection by the immune system. CD47 is a receptor for thrombospondin-1 and their association influences cell migration and adhesion. CD47 is a receptor for SIRP1 and their association influences inhibition of phagocytosis. CD47 is a receptor for several integrins and their association influences cell migration and adhesion. CD47 leads to cell death via apoptosis. <ref>PMID:22310103</ref> | |||
== Relevance == | |||
Antibodies against CD47 were found to bring effective cure against cancer in mice in a variety of cancers tested. CD47 is an antigen on a variety of human cancer cells. | |||
== Structural insights == | |||
CD47 consists of an extracellular N-terminal immunoglobulin-like domain, a transmembrane domain and a C-terminal intracellular domain. | |||
*<scene name='53/538855/Cv/3'>CD47 with SIRP α (cyan) and I-ions</scene> ([[2jjs]]).<ref>PMID:18657508</ref> | |||
</StructureSection> | |||
== 3D Structures of CD47 == | == 3D Structures of CD47 == | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[7ygg]] – hCD47 extracellular domain 19-141 + SIRP α - human<br /> | |||
[[2jjs]], [[2jjt]], [[4kjy]] – hCD47 extracellular domain (mutant) + SIRP α <br /> | [[2jjs]], [[2jjt]], [[4kjy]] – hCD47 extracellular domain (mutant) + SIRP α <br /> | ||
[[2vsc]] – hCD47 extracellular domain (mutant) <br /> | [[2vsc]] – hCD47 extracellular domain (mutant) <br /> | ||
[[4cmm]] - hCD47 extracellular domain (mutant) + tyrosine-protein phosphatase non-receptor type substrate<br /> | [[4cmm]] - hCD47 extracellular domain (mutant) + tyrosine-protein phosphatase non-receptor type substrate<br /> | ||
[[5iwl]] – hCD47 extracellular domain (mutant) + 5F9 diabody <br /> | |||
[[7wn8]] – hCD47 + antibody <br /> | |||
[[7xjf]], [[8rp8]] – hCD47 extracellular domain + antibody <br /> | |||
[[5tz2]], [[5tzt]], [[5tzu]] – hCD47 extracellular domain (mutant) + antibody <br /> | |||
[[7myz]] – hCD47 extracellular domain/cytochrome b562 + antibody <br /> | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 08:39, 20 January 2025
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3D Structures of CD47
Updated on 20-January-2025
2jjs – hCD47 extracellular domain 19-141 + SIRP α - human
2jjs, 2jjt, 4kjy – hCD47 extracellular domain (mutant) + SIRP α
2vsc – hCD47 extracellular domain (mutant)
4cmm - hCD47 extracellular domain (mutant) + tyrosine-protein phosphatase non-receptor type substrate
5iwl – hCD47 extracellular domain (mutant) + 5F9 diabody
7wn8 – hCD47 + antibody
7xjf, 8rp8 – hCD47 extracellular domain + antibody
5tz2, 5tzt, 5tzu – hCD47 extracellular domain (mutant) + antibody
7myz – hCD47 extracellular domain/cytochrome b562 + antibody
