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| <StructureSection load="3fm7" size="400" color="" spin="on" Scene='Dynein/Dynein/3' caption='Dynein light (grey, magenta, cyan and green) and intermediate (pink and yellow) chains, [[3fm7]]' > | | <StructureSection load="" size="350" color="" spin="on" Scene='Dynein/Dynein/3' caption='Dynein light (grey, magenta, cyan and green) and intermediate (pink and yellow) chains, [[3fm7]]' > |
| [[Image:3fm7.png|left|200px|thumb|Crystal Structure of Dynein, [[3fm7]]]]
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| '''Dynein''' is a motor protein which walks along the microtubule toward its minus end, i.e. it is a minus-end directed motor. Dyneins are classified as cytoplasmic (DYNC) or axonemal. The Dyneins are composed of heavy, intermediate and light chains. For discussion of the DYNC inter mediate and light chains see: [[Dynein light and intermediate chain]]. | | '''Dynein''' is a motor protein which walks along the microtubule toward its minus end, i.e. it is a minus-end directed motor. Dyneins are classified as cytoplasmic (DYNC) or axonemal. The '''cytoplasmic dyneins''' are composed of heavy, intermediate and light chains. They drive processes like cell migration, spindle organisation and chromosome separation in mitosis. For discussion of the DYNC intermediate and light chains see: [[Dynein light and intermediate chain]]. '''Axonemal dynein''' has only heavy chain and is involved in cilia and flagella movement. |
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| ==Quaternary Structure of Drosophila melanogaster IC/Tctex-1/LC8; Allosteric Interactions of Dynein Light Chains with Dynein Intermediate Chain== | | ==Quaternary Structure of Drosophila melanogaster IC/Tctex-1/LC8; Allosteric Interactions of Dynein Light Chains with Dynein Intermediate Chain== |
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| == 3D Structures of Dynein == | | == 3D Structures of Dynein == |
| | [[Dynein 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
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| ===Dynein light chain===
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| [[3dvt]], [[3bri]] - DmDYNC light chain - ''Drosophila melanogaster'' <BR />
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| [[3dvh]] - DmDYNC light chain (mutant) <BR />
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| [[1rhw]] - DmDYNC light chain - NMR<BR />
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| [[1ygt]] - DmDYNC light chain TcTex1<BR />
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| [[2e8j]], [[2b95]], [[1z09]] - hDYNC light chain 2A – human – NMR<BR />
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| [[2hz5]] - hDYNC light chain 2A<BR />
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| [[2xqq]] - hDYNC light chain 2 + peptide<br />
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| [[3p8m]] - hDYNC light chain 2 + GCN4<br />
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| [[3zke]], [[3zkf]] - hDYNC light chain + NEK9 peptide<br />
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| [[3tq7]] – hDYNC + EB1C/EB3C<br />
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| [[1y4o]] - mDYNC light chain 2A – mouse<BR />
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| [[1re6]] - mDYNC light chain 2 – NMR<BR />
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| [[1pwj]], [[1pwk]], [[1f3c]] - rDYNC light chain 2 – rat – NMR<BR />
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| [[1f95]], [[1f96]] - rDYNC light chain + peptide – NMR<BR />
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| [[3dvp]], [[3brl]], [[3e2b]] - DmDYNC light chain + peptide<BR />
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| [[1yo3]] – DYNC light chain 1 – ''Plasmodium falciparum''<BR />
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| [[1xdx]], [[1m9l]], [[1ds9]] - CrDYNC light chain TcTex1 – ''Chlamydomonas reinhardtii'' – NMR<BR />
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| [[4ds1]] - yDYNC light chain + nucleoporin Nup129 peptide - yeast<br />
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| [[4ht6]] – yDYNC + PAC11 peptide<br />
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| [[3rjs]] - DYNC light chain – ''Toxoplasma gondii''
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| ===Dynein intermediate chain===
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| [[3l7h]] – DmDYNC intermediate chain light chain roadblock <BR />
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| [[3l9k]] - DmDYNC intermediate chain light chain roadblock + intermediate chain<BR />
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| [[3fm7]], [[3glw]], [[2pg1]], [[2p2t]] - DmDYNC intermediate chain + light chain
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| ===Dynein heavy chain===
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| [[3qmz]] – yDYNC heavy chain + glutathione-S-transferase <BR />
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| [[3err]] - mDYNC heavy chain microtubule-binding domain/Ser-tRNA synthetase<br />
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| [[3j1t]] - mDYNC heavy chain + tubulin α-1B chain<br />
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| [[3j1u]] - mDYNC heavy chain + tubulin α-1B+β-2B chains<br />
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| [[3ay1]], [[3vkg]], [[3vkh]] - DYNC heavy chain – ''Dictyostelium discoideum''<br />
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| [[2rr7]] – CrDYNC microtubule-binding domain<br />
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| [[4aki]], [[4akg]] – yDYNC motor domain + ATP<br />
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| [[4akh]] – yDYNC motor domain + AMPPNP<br />
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| [[4ai6]] – yDYNC motor domain + ADP<br /
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| </StructureSection>
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| ==References== | | ==References== |
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