2mt6: Difference between revisions
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New page: '''Unreleased structure''' The entry 2mt6 is ON HOLD Authors: Vittal, V., Shi, L., Wenzel, D.M., Brzovic, P.S., Klevit, R.E. Description: Solution structure of the human ubiquitin conj... |
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==Solution structure of the human ubiquitin conjugating enzyme Ube2w== | |||
<StructureSection load='2mt6' size='340' side='right'caption='[[2mt6]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2mt6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MT6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MT6 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mt6 OCA], [https://pdbe.org/2mt6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mt6 RCSB], [https://www.ebi.ac.uk/pdbsum/2mt6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mt6 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/UBE2W_HUMAN UBE2W_HUMAN] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Transfers ubiquitin in complex with RING/U-box type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and preferentially ubiquitinates the N-terminus of substrates, such as ATXN3, STUB1 and SUMO2.<ref>PMID:19111657</ref> <ref>PMID:20061386</ref> <ref>PMID:21229326</ref> <ref>PMID:23560854</ref> <ref>PMID:23696636</ref> | |||
==See Also== | |||
*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Brzovic PS]] | |||
[[Category: Klevit RE]] | |||
[[Category: Shi L]] | |||
[[Category: Vittal V]] | |||
[[Category: Wenzel DM]] | |||
Latest revision as of 07:02, 1 May 2024
Solution structure of the human ubiquitin conjugating enzyme Ube2w
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