4r4a: Difference between revisions
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New page: '''Unreleased structure''' The entry 4r4a is ON HOLD Authors: Mandal, P. K. , Collie, G. W., Kauffmann, B., Huc, I. Description: Racemic crystal structure of a cobalt-bound B-DNA duple... |
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==Racemic crystal structure of a cobalt-bound B-DNA duplex== | |||
<StructureSection load='4r4a' size='340' side='right'caption='[[4r4a]], [[Resolution|resolution]] 1.49Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4r4a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R4A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R4A FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.49Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r4a OCA], [https://pdbe.org/4r4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r4a RCSB], [https://www.ebi.ac.uk/pdbsum/4r4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r4a ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Racemates increase the chances of crystallization by allowing molecular contacts to be formed in a greater number of ways. With the advent of protein synthesis, the production of protein racemates and racemic-protein crystallography are now possible. Curiously, racemic DNA crystallography had not been investigated despite the commercial availability of L- and D-deoxyribo-oligonucleotides. Here, we report a study into racemic DNA crystallography showing the strong propensity of racemic DNA mixtures to form racemic crystals. We describe racemic crystal structures of various DNA sequences and folded conformations, including duplexes, quadruplexes, and a four-way junction, showing that the advantages of racemic crystallography should extend to DNA. | |||
Racemic DNA Crystallography.,Mandal PK, Collie GW, Kauffmann B, Huc I Angew Chem Int Ed Engl. 2014 Oct 30. doi: 10.1002/anie.201409014. PMID:25358289<ref>PMID:25358289</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4r4a" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Collie GW]] | |||
[[Category: Huc I]] | |||
[[Category: Kauffmann B]] | |||
[[Category: Mandal PK]] | |||
Latest revision as of 17:43, 20 September 2023
Racemic crystal structure of a cobalt-bound B-DNA duplex
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