1e17: Difference between revisions

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[[Image:1e17.gif|left|200px]]


{{Structure
==Solution structure of the DNA binding domain of the human Forkhead transcription factor AFX (FOXO4)==
|PDB= 1e17 |SIZE=350|CAPTION= <scene name='initialview01'>1e17</scene>
<StructureSection load='1e17' size='340' side='right'caption='[[1e17]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1e17]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E17 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e17 OCA], [https://pdbe.org/1e17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e17 RCSB], [https://www.ebi.ac.uk/pdbsum/1e17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e17 ProSAT]</span></td></tr>
}}
</table>
== Disease ==
[https://www.uniprot.org/uniprot/FOXO4_HUMAN FOXO4_HUMAN] A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X;11)(q13;q23) with KMT2A/MLL1. The result is a rogue activator protein.
== Function ==
[https://www.uniprot.org/uniprot/FOXO4_HUMAN FOXO4_HUMAN] Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.<ref>PMID:10217147</ref> <ref>PMID:10783894</ref> <ref>PMID:12761217</ref> <ref>PMID:15126506</ref> <ref>PMID:16054032</ref> <ref>PMID:16964248</ref> <ref>PMID:20874444</ref> <ref>PMID:22972301</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e1/1e17_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e17 ConSurf].
<div style="clear:both"></div>


'''SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF THE HUMAN FORKHEAD TRANSCRIPTION FACTOR AFX (FOXO4)'''
==See Also==
 
*[[FOX 3D structures|FOX 3D structures]]
 
== References ==
==About this Structure==
<references/>
1E17 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E17 OCA].
__TOC__
 
</StructureSection>
==Reference==
1H, 13C and 15N resonance assignments of the DNA binding domain of the human forkhead transcription factor AFX., Weigelt J, Climent I, Dahlman-Wright K, Wikstrom M, J Biomol NMR. 2000 Jun;17(2):181-2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10921784 10921784]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Climent, I.]]
[[Category: Climent I]]
[[Category: Dahlman-Wright, K.]]
[[Category: Dahlman-Wright K]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Wikstrom, M.]]
[[Category: Wikstrom M]]
[[Category: dna binding domain]]
[[Category: winged helix]]
 
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Retrieved from "https://proteopedia.org/1e17"