4r44: Difference between revisions
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==Racemic crystal structure of a tetramolecular DNA G-quadruplex== | |||
<StructureSection load='4r44' size='340' side='right'caption='[[4r44]], [[Resolution|resolution]] 2.69Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4r44]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R44 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.695Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r44 OCA], [https://pdbe.org/4r44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r44 RCSB], [https://www.ebi.ac.uk/pdbsum/4r44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r44 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Racemates increase the chances of crystallization by allowing molecular contacts to be formed in a greater number of ways. With the advent of protein synthesis, the production of protein racemates and racemic-protein crystallography are now possible. Curiously, racemic DNA crystallography had not been investigated despite the commercial availability of L- and D-deoxyribo-oligonucleotides. Here, we report a study into racemic DNA crystallography showing the strong propensity of racemic DNA mixtures to form racemic crystals. We describe racemic crystal structures of various DNA sequences and folded conformations, including duplexes, quadruplexes, and a four-way junction, showing that the advantages of racemic crystallography should extend to DNA. | |||
Racemic DNA Crystallography.,Mandal PK, Collie GW, Kauffmann B, Huc I Angew Chem Int Ed Engl. 2014 Oct 30. doi: 10.1002/anie.201409014. PMID:25358289<ref>PMID:25358289</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4r44" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Collie GW]] | |||
[[Category: Huc I]] | |||
[[Category: Kauffmann B]] | |||
[[Category: Mandal PK]] | |||
Latest revision as of 17:43, 20 September 2023
Racemic crystal structure of a tetramolecular DNA G-quadruplex
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