4w80: Difference between revisions
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New page: '''Unreleased structure''' The entry 4w80 is ON HOLD until Paper Publication Authors: Quistgaard, E.M. Description: Tetrameric BAP29 vDED with disulfide bonds in crystal contacts |
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==Tetrameric BAP29 vDED with disulfide bonds in crystal contacts== | |||
<StructureSection load='4w80' size='340' side='right'caption='[[4w80]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4w80]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W80 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w80 OCA], [https://pdbe.org/4w80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w80 RCSB], [https://www.ebi.ac.uk/pdbsum/4w80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w80 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BAP29_HUMAN BAP29_HUMAN] May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity). | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The vDED coiled coil domain from human BAP29 was crystallized in dimeric and tetrameric forms. For the dimer, a disulfide bond was unexpectedly found to bridge a crystal contact, resulting in complete cross-linking along the c-axis. This indicates that it is in principle possible to design spontaneously polymerizing protein crystals. | |||
A disulfide polymerized protein crystal.,Quistgaard EM Chem Commun (Camb). 2014 Oct 20. PMID:25327138<ref>PMID:25327138</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4w80" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Quistgaard EM]] | |||
Latest revision as of 10:41, 10 January 2024
Tetrameric BAP29 vDED with disulfide bonds in crystal contacts
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