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==Crystal structure of PBP2a clinical mutant N146K from MRSA==
==Crystal structure of PBP2a clinical mutant N146K from MRSA==
<StructureSection load='4bl3' size='340' side='right' caption='[[4bl3]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='4bl3' size='340' side='right'caption='[[4bl3]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4bl3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BL3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BL3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4bl3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BL3 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bl2|4bl2]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MUR:MURAMIC+ACID'>MUR</scene></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine-type_D-Ala-D-Ala_carboxypeptidase Serine-type D-Ala-D-Ala carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.16.4 3.4.16.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bl3 OCA], [https://pdbe.org/4bl3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bl3 RCSB], [https://www.ebi.ac.uk/pdbsum/4bl3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bl3 ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bl3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bl3 RCSB], [http://www.ebi.ac.uk/pdbsum/4bl3 PDBsum]</span></td></tr>
</table>
<table>
== Function ==
[https://www.uniprot.org/uniprot/A0A0H3JPA5_STAAM A0A0H3JPA5_STAAM]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4bl3" style="background-color:#fffaf0;"></div>
==See Also==
*[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Serine-type D-Ala-D-Ala carboxypeptidase]]
[[Category: Large Structures]]
[[Category: Carrasco-Lopez, C.]]
[[Category: Staphylococcus aureus]]
[[Category: Hermoso, J A.]]
[[Category: Carrasco-Lopez C]]
[[Category: Otero, L H.]]
[[Category: Hermoso JA]]
[[Category: Rojas-Altuve, A.]]
[[Category: Otero LH]]
[[Category: Allosteric site]]
[[Category: Rojas-Altuve A]]
[[Category: B-lactam antibiotic]]
[[Category: Hydrolase]]
[[Category: Mrsa]]

Latest revision as of 11:53, 20 December 2023

Crystal structure of PBP2a clinical mutant N146K from MRSA

4bl3, resolution 3.00Å

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