2mu8: Difference between revisions
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==Residues belonging the n-terminal region derived of merozoite surface protein-2 of plasmodium falciparum== | |||
<StructureSection load='2mu8' size='340' side='right'caption='[[2mu8]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2mu8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MU8 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mu8 OCA], [https://pdbe.org/2mu8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mu8 RCSB], [https://www.ebi.ac.uk/pdbsum/2mu8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mu8 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MSA2_PLAF7 MSA2_PLAF7] May play a role in the merozoite attachment to the erythrocyte. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The conserved, nonantigenic, nonimmunogenic malaria Merozoite Surface Protein-2 peptide 1, having high affinity for red blood cells, was rendered immunogenic and protective in Aotus monkeys by specifically changing some critical residues. The NMR structure revealed a switch from classical type III' into distorted III' and III beta turns in the protective peptides. These changes may lead to a better fit into the Aotus MHC class II human HLA-DRbeta1 12 molecule equivalent, thus activating the immune system. | |||
Distorting malaria peptide backbone structure to enable fitting into MHC class II molecules renders modified peptides immunogenic and protective.,Cifuentes G, Patarroyo ME, Urquiza M, Ramirez LE, Reyes C, Rodriguez R J Med Chem. 2003 May 22;46(11):2250-3. PMID:12747797<ref>PMID:12747797</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2mu8" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Plasmodium falciparum]] | |||
[[Category: Cifuentes G]] | |||
[[Category: Patarroyo ME]] | |||
[[Category: Ramirez LE]] | |||
[[Category: Reyes C]] | |||
[[Category: Rodriguez R]] | |||
[[Category: Urquiza M]] | |||
Latest revision as of 06:10, 15 May 2024
Residues belonging the n-terminal region derived of merozoite surface protein-2 of plasmodium falciparum
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