4r89: Difference between revisions
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New page: '''Unreleased structure''' The entry 4r89 is ON HOLD Authors: Cho, Y., Gwon, G.H., Kim, Y.R. Description: nuclease_metal |
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==Crystal structure of paFAN1 - 5' flap DNA complex with Manganase== | |||
<StructureSection load='4r89' size='340' side='right'caption='[[4r89]], [[Resolution|resolution]] 4.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4r89]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R89 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.002Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r89 OCA], [https://pdbe.org/4r89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r89 RCSB], [https://www.ebi.ac.uk/pdbsum/4r89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r89 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/FAN1_PSEAE FAN1_PSEAE] Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Also has endonuclease activity toward 5'-flaps (PubMed:25319828).[UniProtKB:Q9Y2M0]<ref>PMID:24981866</ref> <ref>PMID:25319828</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Pseudomonas aeruginosa PAO1]] | |||
[[Category: Cho Y]] | |||
[[Category: Gwon GH]] | |||
[[Category: Kim YR]] | |||
Latest revision as of 08:59, 20 March 2024
Crystal structure of paFAN1 - 5' flap DNA complex with Manganase
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