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==Crystal structure of DNA polymerase sliding clamp from Pseudomonas aeruginosa==
==Crystal structure of DNA polymerase sliding clamp from Pseudomonas aeruginosa==
<StructureSection load='4tr8' size='340' side='right' caption='[[4tr8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='4tr8' size='340' side='right'caption='[[4tr8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4tr8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TR8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TR8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4tr8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_HB15 Pseudomonas aeruginosa HB15]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TR8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TR8 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tr8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tr8 RCSB], [http://www.ebi.ac.uk/pdbsum/4tr8 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tr8 OCA], [https://pdbe.org/4tr8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tr8 RCSB], [https://www.ebi.ac.uk/pdbsum/4tr8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tr8 ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DPO3B_PSEAE DPO3B_PSEAE] Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.[UniProtKB:P0A988]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4tr8" style="background-color:#fffaf0;"></div>
==See Also==
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: DNA-directed DNA polymerase]]
[[Category: Large Structures]]
[[Category: Burnouf, D.]]
[[Category: Pseudomonas aeruginosa HB15]]
[[Category: Ennifar, E.]]
[[Category: Burnouf D]]
[[Category: Olieric, V.]]
[[Category: Ennifar E]]
[[Category: Wolff, P.]]
[[Category: Olieric V]]
[[Category: Dna binding protein]]
[[Category: Wolff P]]
[[Category: Dna polymerase]]
[[Category: Processivity]]
[[Category: Sliding clamp]]
Retrieved from "https://proteopedia.org/4tr8"