4c3z: Difference between revisions

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==Nucleotide-free crystal structure of nucleotide-binding domain 1 from human MRP1 supports a general-base catalysis mechanism for ATP hydrolysis.==
==Nucleotide-free crystal structure of nucleotide-binding domain 1 from human MRP1 supports a general-base catalysis mechanism for ATP hydrolysis.==
<StructureSection load='4c3z' size='340' side='right' caption='[[4c3z]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='4c3z' size='340' side='right'caption='[[4c3z]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4c3z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C3Z FirstGlance]. <br>
<table><tr><td colspan='2'>[[4c3z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C3Z FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c3z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c3z RCSB], [http://www.ebi.ac.uk/pdbsum/4c3z PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<table>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c3z OCA], [https://pdbe.org/4c3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c3z RCSB], [https://www.ebi.ac.uk/pdbsum/4c3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c3z ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MRP1_HUMAN MRP1_HUMAN] Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.<ref>PMID:10064732</ref> <ref>PMID:11114332</ref> <ref>PMID:16230346</ref>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: BaubichonCortay, H.]]
[[Category: Homo sapiens]]
[[Category: Chaptal, V.]]
[[Category: Large Structures]]
[[Category: DiPietro, A.]]
[[Category: Baubichon-Cortay H]]
[[Category: Falson, P.]]
[[Category: Chaptal V]]
[[Category: GueguenChaignon, V.]]
[[Category: Di Pietro A]]
[[Category: Magnard, S.]]
[[Category: Falson P]]
[[Category: Atp-binding cassette transporter]]
[[Category: Gueguen-Chaignon V]]
[[Category: General-base mechanism]]
[[Category: Magnard S]]
[[Category: Multidrug resistance protein 1]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/4c3z"