1e9w: Difference between revisions

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[[Image:1e9w.gif|left|200px]]


{{Structure
==Structure of the macrocycle thiostrepton solved using the anomalous dispersive contribution from sulfur==
|PDB= 1e9w |SIZE=350|CAPTION= <scene name='initialview01'>1e9w</scene>, resolution 1.02&Aring;
<StructureSection load='1e9w' size='340' side='right'caption='[[1e9w]], [[Resolution|resolution]] 1.02&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=TZO:1,3-THIAZOLE-4-CARBOXYLIC+ACID'>TZO</scene>, <scene name='pdbligand=TZB:(4S)-2-[(1E)-1-AMINOPROP-1-ENYL]-4,5-DIHYDRO-1,3-THIAZOLE-4-CARBOXYLIC+ACID'>TZB</scene>, <scene name='pdbligand=TZO:1,3-THIAZOLE-4-CARBOXYLIC+ACID'>TZO</scene>, <scene name='pdbligand=QUA:8-HYDROXY-4-(1-HYDROXYETHYL)QUINOLINE-2-CARBOXYLIC+ACID'>QUA</scene> and <scene name='pdbligand=XBB:(3S)-2,3,4,5-TETRAHYDROPYRIDIN-3-AMINE'>XBB</scene>
<table><tr><td colspan='2'>[[1e9w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_azureus Streptomyces azureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E9W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E9W FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.02&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BB9:(2Z)-2-AMINO-3-SULFANYLPROP-2-ENOIC+ACID'>BB9</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=MH6:3-HYDROXY-2-IMINOPROPANOIC+ACID'>MH6</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PRD_000223:THIOSTREPTON'>PRD_000223</scene>, <scene name='pdbligand=QUA:8-HYDROXY-4-(1-HYDROXYETHYL)QUINOLINE-2-CARBOXYLIC+ACID'>QUA</scene>, <scene name='pdbligand=TS9:(2S,3S,4R)-2-AMINO-3,4-DIHYDROXY-3-METHYLPENTANOIC+ACID'>TS9</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e9w OCA], [https://pdbe.org/1e9w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e9w RCSB], [https://www.ebi.ac.uk/pdbsum/1e9w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e9w ProSAT]</span></td></tr>
 
</table>
'''STRUCTURE OF THE MACROCYCLE THIOSTREPTON SOLVED USING THE ANOMALOUS DISPERSIVE CONTRIBUTION FROM SULFUR'''
== Function ==
 
[https://www.uniprot.org/uniprot/THCL_STRAJ THCL_STRAJ] Has bacteriocidal activity. Inhibits bacterial protein biosynthesis by acting on the elongation factor Tu (EF-Tu) (By similarity).
 
__TOC__
==Overview==
</StructureSection>
The structure of a tetragonal crystal form of thiostrepton has been solved using the anomalous dispersive effects of five S atoms from high-redundancy data collected to 1.33 A resolution at the Cu Kalpha wavelength. Data measured to 1.02 A resolution with a synchrotron source were used for refinement. Details of the molecular structure, intramolecular and intermolecular interactions are given.
[[Category: Large Structures]]
 
==About this Structure==
1E9W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_azureus Streptomyces azureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E9W OCA].
 
==Reference==
Structure of the macrocycle thiostrepton solved using the anomalous dispersion contribution of sulfur., Bond CS, Shaw MP, Alphey MS, Hunter WN, Acta Crystallogr D Biol Crystallogr. 2001 May;57(Pt 5):755-8. Epub 2001, Apr 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11320328 11320328]
[[Category: Single protein]]
[[Category: Streptomyces azureus]]
[[Category: Streptomyces azureus]]
[[Category: Alphey, M S.]]
[[Category: Alphey MS]]
[[Category: Bond, C S.]]
[[Category: Bond CS]]
[[Category: Hunter, W N.]]
[[Category: Hunter WN]]
[[Category: Shaw, M P.]]
[[Category: Shaw MP]]
[[Category: QUA]]
[[Category: TZB]]
[[Category: TZO]]
[[Category: XBB]]
[[Category: antibiotic]]
[[Category: ribosome]]
[[Category: thioazole]]
[[Category: translation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:52:23 2008''
Retrieved from "https://proteopedia.org/1e9w"