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==Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD and NADP==
==Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD and NADP==
<StructureSection load='4cqm' size='340' side='right' caption='[[4cqm]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
<StructureSection load='4cqm' size='340' side='right'caption='[[4cqm]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4cqm]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CQM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CQM FirstGlance]. <br>
<table><tr><td colspan='2'>[[4cqm]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CQM FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene><br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=OAS:O-ACETYLSERINE'>OAS</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OAS:O-ACETYLSERINE'>OAS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cqm OCA], [https://pdbe.org/4cqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cqm RCSB], [https://www.ebi.ac.uk/pdbsum/4cqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cqm ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cql|4cql]]</td></tr>
</table>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-oxoacyl-[acyl-carrier-protein]_reductase 3-oxoacyl-[acyl-carrier-protein] reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100] </span></td></tr>
== Function ==
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cqm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cqm RCSB], [http://www.ebi.ac.uk/pdbsum/4cqm PDBsum]</span></td></tr>
[[https://www.uniprot.org/uniprot/DHB8_HUMAN DHB8_HUMAN]] NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria.<ref>PMID:17978863</ref> <ref>PMID:19571038</ref>  
<table>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4cqm" style="background-color:#fffaf0;"></div>
==See Also==
*[[Carbonyl reductase 3D structures|Carbonyl reductase 3D structures]]
*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Awoniyi, L O.]]
[[Category: Homo sapiens]]
[[Category: Chen, Z.]]
[[Category: Large Structures]]
[[Category: Hiltunen, J K.]]
[[Category: Awoniyi LO]]
[[Category: Jiang, G.]]
[[Category: Chen Z]]
[[Category: Kastoniotis, A J.]]
[[Category: Hiltunen JK]]
[[Category: Prus, P.]]
[[Category: Jiang G]]
[[Category: SahTeli, S K.]]
[[Category: Kastoniotis AJ]]
[[Category: Venkatesan, R.]]
[[Category: Prus P]]
[[Category: Wierenga, R K.]]
[[Category: SahTeli SK]]
[[Category: 17-beta hydroxysteroid dehydrogenase]]
[[Category: Venkatesan R]]
[[Category: 3-ketoacyl-acp reductase]]
[[Category: Wierenga RK]]
[[Category: 3r-hydroxyacyl-coa dehydrogenase]]
[[Category: Carbobyl reductase type4]]
[[Category: Cbr4]]
[[Category: Hetero tetramer]]
[[Category: Hsd17b8]]
[[Category: Hsd8]]
[[Category: Kar]]
[[Category: Ke6]]
[[Category: Ketoacyl reductase]]
[[Category: Nad]]
[[Category: Nadh]]
[[Category: Nadp]]
[[Category: Nadph]]
[[Category: Oxidoreductase]]
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