4rbs: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 4rbs is ~~ON HOLD~~

==Crystal Structure of New Delhi Metallo-beta-Lactamase-1 in the Complex with Hydrolyzed Meropenem==

== Structural highlights ==

<table><tr><td colspan='2'>[[4rbs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RBS OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4RBS FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.405Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0RV:(2S)-2-[(1S,2R)-1-CARBOXY-2-HYDROXYPROPYL]-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-3-METHYL-2H-PYRROLE-5-CARBOXYLIC+ACID'>0RV</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4rbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rbs OCA], [https://pdbe.org/4rbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rbs RCSB], [https://www.ebi.ac.uk/pdbsum/4rbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rbs ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.

~~Authors~~: ~~Kim, Y., Tesar, C.,~~ Jedrzejczak, R~~., Babnigg, G., Sacchettini, J.,~~ Joachimiak, A~~., Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI)~~

==See Also==

*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]

~~Description~~: ~~Crystal Structure of New Delhi Metallo-beta-Lactamase-1 in the Complex with Hydrolyzed Meropenem~~

__TOC__

</StructureSection>

[[Category: Klebsiella pneumoniae]]

[[Category: Large Structures]]

[[Category: Babnigg G]]

[[Category: Jedrzejczak R]]

[[Category: Joachimiak A]]

[[Category: Kim Y]]

[[Category: Sacchettini J]]

[[Category: Tesar C]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4rbs is ON HOLD
+==Crystal Structure of New Delhi Metallo-beta-Lactamase-1 in the Complex with Hydrolyzed Meropenem==
+<StructureSection load='4rbs' size='340' side='right'caption='[[4rbs]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4rbs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RBS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RBS FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.405&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0RV:(2S)-2-[(1S,2R)-1-CARBOXY-2-HYDROXYPROPYL]-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-3-METHYL-2H-PYRROLE-5-CARBOXYLIC+ACID'>0RV</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rbs OCA], [https://pdbe.org/4rbs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rbs RCSB], [https://www.ebi.ac.uk/pdbsum/4rbs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rbs ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
-Authors: Kim, Y., Tesar, C., Jedrzejczak, R., Babnigg, G., Sacchettini, J., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI)
+==See Also==
+*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
-Description: Crystal Structure of New Delhi Metallo-beta-Lactamase-1 in the Complex with Hydrolyzed Meropenem
+__TOC__
+</StructureSection>
+[[Category: Klebsiella pneumoniae]]
+[[Category: Large Structures]]
+[[Category: Babnigg G]]
+[[Category: Jedrzejczak R]]
+[[Category: Joachimiak A]]
+[[Category: Kim Y]]
+[[Category: Sacchettini J]]
+[[Category: Tesar C]]