4qpq: Difference between revisions
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==Mechanistic basis of plasmid-specific DNA binding of the F plasmid regulatory protein, TraM== | ==Mechanistic basis of plasmid-specific DNA binding of the F plasmid regulatory protein, TraM== | ||
<StructureSection load='4qpq' size='340' side='right' caption='[[4qpq]], [[Resolution|resolution]] 3.11Å' scene=''> | <StructureSection load='4qpq' size='340' side='right'caption='[[4qpq]], [[Resolution|resolution]] 3.11Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4qpq]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QPQ OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4qpq]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QPQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QPQ FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.106Å</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qpq OCA], [https://pdbe.org/4qpq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qpq RCSB], [https://www.ebi.ac.uk/pdbsum/4qpq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qpq ProSAT]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/TRAM1_ECOLI TRAM1_ECOLI] Conjugative DNA transfer (CDT) is the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Part of the relaxosome, which facilitates a site- and strand-specific cut in the origin of transfer by TraI, at the nic site. Cooperatively binds 3 regions in the F plasmid oriT locus; 2 are required for autoregulation while the other is required for plasmid transfer. Bends oriT DNA less than 50 degrees. Plasmid specificity is conferred by the TraD-TraM pair.<ref>PMID:1479887</ref> <ref>PMID:8736534</ref> <ref>PMID:11875064</ref> <ref>PMID:17238924</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Escherichia coli K-12]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Edwards RA]] | ||
[[Category: | [[Category: Frost LS]] | ||
[[Category: | [[Category: Glover JNM]] | ||
[[Category: | [[Category: Lu J]] | ||
[[Category: | [[Category: Peng Y]] | ||
[[Category: | [[Category: Wong J]] | ||
Latest revision as of 12:47, 1 March 2024
Mechanistic basis of plasmid-specific DNA binding of the F plasmid regulatory protein, TraM
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