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==PSORALEN CROSS-LINKED D(CCGGTACCGG) FORMS HOLLIDAY JUNCTION==
==PSORALEN CROSS-LINKED D(CCGGTACCGG) FORMS HOLLIDAY JUNCTION==
<StructureSection load='1fhz' size='340' side='right' caption='[[1fhz]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='1fhz' size='340' side='right'caption='[[1fhz]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1fhz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FHZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[1fhz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FHZ FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PSO:4-HYDROXYMETHYL-4,5,8-TRIMETHYLPSORALEN'>PSO</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fhz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1fhz RCSB], [http://www.ebi.ac.uk/pdbsum/1fhz PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PSO:4-HYDROXYMETHYL-4,5,8-TRIMETHYLPSORALEN'>PSO</scene></td></tr>
<table>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fhz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fhz OCA], [https://pdbe.org/1fhz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fhz RCSB], [https://www.ebi.ac.uk/pdbsum/1fhz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fhz ProSAT]</span></td></tr>
<div style="background-color:#fffaf0;">
</table>
== Publication Abstract from PubMed ==
The single-crystal structures are presented for two DNA sequences with the thymine bases covalently cross-linked across the complementary strands by 4'-hydroxymethyl-4,5',8-trimethylpsoralen (HMT). The HMT-adduct of d(CCGCTAGCGG) forms a psoralen-induced Holliday junction, showing for the first time the effect of this important class of chemotheraputics on the structure of the recombination intermediate. In contrast, HMT-d(CCGGTACCGG) forms a sequence-dependent junction. In both structures, the DNA duplex is highly distorted at the thymine base linked to the six-member pyrone ring of the drug. The psoralen cross-link defines the intramolecular interactions of the drug-induced junction, while the sequence-dependent structure is nearly identical to the native Holliday junction of d(CCGGTACCGG) alone. The two structures contrast the effects of drug- and sequence-dependent interactions on the structure of a Holliday junction, suggesting a role for psoralen in the mechanism to initiate repair of psoralen-lesions in mammalian DNA.
 
The crystal structures of psoralen cross-linked DNAs: drug-dependent formation of Holliday junctions.,Eichman BF, Mooers BH, Alberti M, Hearst JE, Ho PS J Mol Biol. 2001 Apr 20;308(1):15-26. PMID:11302703<ref>PMID:11302703</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Alberti, M.]]
[[Category: Large Structures]]
[[Category: Eichman, B F.]]
[[Category: Alberti M]]
[[Category: Hearst, J E.]]
[[Category: Eichman BF]]
[[Category: Ho, P S.]]
[[Category: Hearst JE]]
[[Category: Mooers, B H.M.]]
[[Category: Ho PS]]
[[Category: Cross-linked dna]]
[[Category: Mooers BHM]]
[[Category: Dna]]
[[Category: Dna-drug complex]]
[[Category: Holliday junction]]
[[Category: Psoralen]]

Latest revision as of 07:14, 7 February 2024

PSORALEN CROSS-LINKED D(CCGGTACCGG) FORMS HOLLIDAY JUNCTION

1fhz, resolution 2.20Å

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