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[[Image:1ezj.gif|left|200px]]


{{Structure
==CRYSTAL STRUCTURE OF THE MULTIMERIZATION DOMAIN OF THE PHOSPHOPROTEIN FROM SENDAI VIRUS==
|PDB= 1ezj |SIZE=350|CAPTION= <scene name='initialview01'>1ezj</scene>, resolution 1.90&Aring;
<StructureSection load='1ezj' size='340' side='right'caption='[[1ezj]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=EMC:ETHYL+MERCURY+ION'>EMC</scene> and <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
<table><tr><td colspan='2'>[[1ezj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sendai_virus_(strain_Harris) Sendai virus (strain Harris)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EZJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EZJ FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EMC:ETHYL+MERCURY+ION'>EMC</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ezj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ezj OCA], [https://pdbe.org/1ezj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ezj RCSB], [https://www.ebi.ac.uk/pdbsum/1ezj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ezj ProSAT]</span></td></tr>
 
</table>
'''CRYSTAL STRUCTURE OF THE MULTIMERIZATION DOMAIN OF THE PHOSPHOPROTEIN FROM SENDAI VIRUS'''
== Function ==
 
[https://www.uniprot.org/uniprot/PHOSP_SENDH PHOSP_SENDH] Essential component of the RNA polymerase transcription and replication complex. Binds the viral ribonucleocapsid and positions the L polymerase on the template.  Acts as a chaperone for newly synthesized free N protein, so-called N(0). Stabilizes the L protein upon binding it.
 
<div style="background-color:#fffaf0;">
==Overview==
== Publication Abstract from PubMed ==
The high resolution X-ray structure of the Sendai virus oligomerization domain reveals a homotetrameric coiled coil structure with many details that are different from classic coiled coils with canonical hydrophobic heptad repeats. Alternatives to the classic knobs-into-holes packing lead to differences in supercoil pitch and diameter that allow water molecules inside the core. This open and more hydrophilic structure does not seem to be destabilized by mutations that would be expected to disrupt classic coiled coils.
The high resolution X-ray structure of the Sendai virus oligomerization domain reveals a homotetrameric coiled coil structure with many details that are different from classic coiled coils with canonical hydrophobic heptad repeats. Alternatives to the classic knobs-into-holes packing lead to differences in supercoil pitch and diameter that allow water molecules inside the core. This open and more hydrophilic structure does not seem to be destabilized by mutations that would be expected to disrupt classic coiled coils.


==About this Structure==
Tetrameric coiled coil domain of Sendai virus phosphoprotein.,Tarbouriech N, Curran J, Ruigrok RW, Burmeister WP Nat Struct Biol. 2000 Sep;7(9):777-81. PMID:10966649<ref>PMID:10966649</ref>
1EZJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sendai_virus Sendai virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EZJ OCA].
 
==Reference==
Tetrameric coiled coil domain of Sendai virus phosphoprotein., Tarbouriech N, Curran J, Ruigrok RW, Burmeister WP, Nat Struct Biol. 2000 Sep;7(9):777-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10966649 10966649]
[[Category: RNA-directed RNA polymerase]]
[[Category: Sendai virus]]
[[Category: Single protein]]
[[Category: Burmeister, W P.]]
[[Category: Curran, J.]]
[[Category: Ruigrok, R W.H.]]
[[Category: Tarbouriech, N.]]
[[Category: CA]]
[[Category: EMC]]
[[Category: four stranded coiled coil]]
[[Category: sendai virus]]
[[Category: tetramer]]
[[Category: viral polymerase]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:02:30 2008''
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1ezj" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Burmeister WP]]
[[Category: Curran J]]
[[Category: Ruigrok RWH]]
[[Category: Tarbouriech N]]

Latest revision as of 05:52, 13 August 2026

CRYSTAL STRUCTURE OF THE MULTIMERIZATION DOMAIN OF THE PHOSPHOPROTEIN FROM SENDAI VIRUS

1ezj, resolution 1.90Å

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