1n3s: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
No edit summary
OCA (talk | contribs)
No edit summary
 
(7 intermediate revisions by the same user not shown)
Line 1: Line 1:
==Biosynthesis of pteridins. Reaction mechanism of GTP cyclohydrolase I==
==Biosynthesis of pteridins. Reaction mechanism of GTP cyclohydrolase I==
<StructureSection load='1n3s' size='340' side='right' caption='[[1n3s]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
<StructureSection load='1n3s' size='340' side='right'caption='[[1n3s]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1n3s]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N3S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1N3S FirstGlance]. <br>
<table><tr><td colspan='2'>[[1n3s]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N3S FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1n3r|1n3r]], [[1n3t|1n3t]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/GTP_cyclohydrolase_I GTP cyclohydrolase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.16 3.5.4.16] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n3s OCA], [https://pdbe.org/1n3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n3s RCSB], [https://www.ebi.ac.uk/pdbsum/1n3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n3s ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n3s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1n3s RCSB], [http://www.ebi.ac.uk/pdbsum/1n3s PDBsum]</span></td></tr>
</table>
<table>
== Function ==
[https://www.uniprot.org/uniprot/GCH1_ECOLI GCH1_ECOLI]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n3/1n3s_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n3/1n3s_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n3s ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
Line 26: Line 28:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 1n3s" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Cyclohydrolase|Cyclohydrolase]]
*[[Cyclohydrolase 3D structures|Cyclohydrolase 3D structures]]
== References ==
== References ==
<references/>
<references/>
Line 34: Line 37:
</StructureSection>
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: GTP cyclohydrolase I]]
[[Category: Large Structures]]
[[Category: Auerbach, G.]]
[[Category: Auerbach G]]
[[Category: Bacher, A.]]
[[Category: Bacher A]]
[[Category: Bader, G.]]
[[Category: Bader G]]
[[Category: Bracher, A.]]
[[Category: Bracher A]]
[[Category: Fischer, M.]]
[[Category: Fischer M]]
[[Category: Hoesl, C.]]
[[Category: Hoesl C]]
[[Category: Huber, R.]]
[[Category: Huber R]]
[[Category: Kaiser, J.]]
[[Category: Kaiser J]]
[[Category: Nar, H.]]
[[Category: Nar H]]
[[Category: Rebelo, J.]]
[[Category: Rebelo J]]
[[Category: Schramek, N.]]
[[Category: Schramek N]]
[[Category: Biosynthesis]]
[[Category: Folic acid]]
[[Category: Gtp cyclohydrolase i]]
[[Category: Hydrolase]]
[[Category: Pteridine]]
[[Category: Tetrahydropterin]]