1t67: Difference between revisions
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==Crystal Structure of Human HDAC8 complexed with MS-344== | ==Crystal Structure of Human HDAC8 complexed with MS-344== | ||
<StructureSection load='1t67' size='340' side='right' caption='[[1t67]], [[Resolution|resolution]] 2.31Å' scene=''> | <StructureSection load='1t67' size='340' side='right'caption='[[1t67]], [[Resolution|resolution]] 2.31Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1t67]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1t67]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T67 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T67 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B3N:4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE'>B3N</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B3N:4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE'>B3N</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t67 OCA], [https://pdbe.org/1t67 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t67 RCSB], [https://www.ebi.ac.uk/pdbsum/1t67 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t67 ProSAT]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/HDAC8_HUMAN HDAC8_HUMAN] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.<ref>PMID:10748112</ref> <ref>PMID:10926844</ref> <ref>PMID:10922473</ref> <ref>PMID:14701748</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t6/1t67_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t6/1t67_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t67 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 1t67" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Histone deacetylase|Histone deacetylase]] | *[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arvai | [[Category: Large Structures]] | ||
[[Category: Buggy | [[Category: Arvai A]] | ||
[[Category: Chi | [[Category: Buggy JJ]] | ||
[[Category: Dougan | [[Category: Chi E]] | ||
[[Category: Ho | [[Category: Dougan DR]] | ||
[[Category: Jennings | [[Category: Ho JD]] | ||
[[Category: Katz | [[Category: Jennings AJ]] | ||
[[Category: Knuth | [[Category: Katz BA]] | ||
[[Category: Leahy | [[Category: Knuth MW]] | ||
[[Category: Luong | [[Category: Leahy EM]] | ||
[[Category: McRee | [[Category: Luong C]] | ||
[[Category: Mol | [[Category: McRee DE]] | ||
[[Category: Navre | [[Category: Mol C]] | ||
[[Category: Sang | [[Category: Navre M]] | ||
[[Category: Skene | [[Category: Sang B-C]] | ||
[[Category: Snell | [[Category: Skene RJ]] | ||
[[Category: Somoza | [[Category: Snell G]] | ||
[[Category: Swanson | [[Category: Somoza JR]] | ||
[[Category: Tang | [[Category: Swanson RV]] | ||
[[Category: Tari | [[Category: Tang J]] | ||
[[Category: Verner | [[Category: Tari LW]] | ||
[[Category: Wynands | [[Category: Verner E]] | ||
[[Category: Wynands R]] | |||
