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==LOW RESOLUTION STRUCTURE OF SPT==
 
<StructureSection load='2jgt' size='340' side='right' caption='[[2jgt]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
==Low resolution structure of SPT==
<StructureSection load='2jgt' size='340' side='right'caption='[[2jgt]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2jgt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sphingomonas_paucimobilis Sphingomonas paucimobilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JGT FirstGlance]. <br>
<table><tr><td colspan='2'>[[2jgt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sphingomonas_paucimobilis Sphingomonas paucimobilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JGT FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine_C-palmitoyltransferase Serine C-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.50 2.3.1.50] </span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jgt RCSB], [http://www.ebi.ac.uk/pdbsum/2jgt PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgt OCA], [https://pdbe.org/2jgt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jgt RCSB], [https://www.ebi.ac.uk/pdbsum/2jgt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jgt ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SPT_SPHPI SPT_SPHPI] Catalyzes the condensation of L-serine with palmitoyl-CoA (hexadecanoyl-CoA) to produce 3-oxosphinganine (PubMed:11279212, PubMed:17557831, PubMed:17559874, PubMed:19376777). Exhibits a broad substrate specificity concerning the chain length and the degree of unsaturation of acyl-CoA (PubMed:11279212, PubMed:19376777).<ref>PMID:11279212</ref> <ref>PMID:17557831</ref> <ref>PMID:17559874</ref> <ref>PMID:19376777</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/2jgt_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/2jgt_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jgt ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2jgt" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Serine palmitoyltransferase|Serine palmitoyltransferase]]
*[[Serine palmitoyltransferase 3D structures|Serine palmitoyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Serine C-palmitoyltransferase]]
[[Category: Large Structures]]
[[Category: Sphingomonas paucimobilis]]
[[Category: Sphingomonas paucimobilis]]
[[Category: Barton, G J.]]
[[Category: Barton GJ]]
[[Category: Campopiano, D J.]]
[[Category: Campopiano DJ]]
[[Category: Carter, L G.]]
[[Category: Carter LG]]
[[Category: Dorward, M.]]
[[Category: Dorward M]]
[[Category: Johnson, K A.]]
[[Category: Johnson KA]]
[[Category: Liu, H.]]
[[Category: Liu H]]
[[Category: Mcmahon, S A.]]
[[Category: Mcmahon SA]]
[[Category: Naismith, J H.]]
[[Category: Naismith JH]]
[[Category: Oke, M.]]
[[Category: Oke M]]
[[Category: Overton, I M.]]
[[Category: Overton IM]]
[[Category: Puech, D.]]
[[Category: Puech D]]
[[Category: Yard, B A.]]
[[Category: Yard BA]]
[[Category: Plp]]
[[Category: Pyridoxal phosphate]]
[[Category: Serine palmitoyl transferase]]
[[Category: Sphingolipid]]
[[Category: Spt]]
[[Category: Sspf]]
[[Category: Transferase]]