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==Crystal structure of the ClpP protease catalytic domain from Plasmodium falciparum==
==Crystal structure of the ClpP protease catalytic domain from Plasmodium falciparum==
<StructureSection load='2f6i' size='340' side='right' caption='[[2f6i]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
<StructureSection load='2f6i' size='340' side='right'caption='[[2f6i]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2f6i]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F6I FirstGlance]. <br>
<table><tr><td colspan='2'>[[2f6i]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F6I FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f6i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f6i RCSB], [http://www.ebi.ac.uk/pdbsum/2f6i PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f6i OCA], [https://pdbe.org/2f6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f6i RCSB], [https://www.ebi.ac.uk/pdbsum/2f6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f6i ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O97252_PLAF7 O97252_PLAF7]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f6/2f6i_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f6/2f6i_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f6i ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2f6i" style="background-color:#fffaf0;"></div>
==See Also==
*[[Clp protease 3D structures|Clp protease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Endopeptidase Clp]]
[[Category: Large Structures]]
[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
[[Category: Amani, M.]]
[[Category: Amani M]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Bray, J.]]
[[Category: Bray J]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Finerty, P.]]
[[Category: Finerty P]]
[[Category: Hui, R.]]
[[Category: Hui R]]
[[Category: Loppnau, P.]]
[[Category: Loppnau P]]
[[Category: Mulichak, A.]]
[[Category: Mulichak A]]
[[Category: Plotnikova, O.]]
[[Category: Plotnikova O]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Vedadi M]]
[[Category: Vedadi, M.]]
[[Category: Wasney G]]
[[Category: Wasney, G.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Clp protease]]
[[Category: Hydrolase]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]

Latest revision as of 07:44, 23 August 2023

Crystal structure of the ClpP protease catalytic domain from Plasmodium falciparum

2f6i, resolution 2.45Å

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