3bm9: Difference between revisions
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==Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90== | ==Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90== | ||
<StructureSection load='3bm9' size='340' side='right' caption='[[3bm9]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='3bm9' size='340' side='right'caption='[[3bm9]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3bm9]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3bm9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BM9 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BXZ:4-BROMO-6-(6-HYDROXY-1,2-BENZISOXAZOL-3-YL)BENZENE-1,3-DIOL'>BXZ</scene></td></tr> | |||
<tr><td class="sblockLbl"><b>[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bm9 OCA], [https://pdbe.org/3bm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bm9 RCSB], [https://www.ebi.ac.uk/pdbsum/3bm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bm9 ProSAT]</span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </table> | ||
<table> | == Function == | ||
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bm/3bm9_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bm/3bm9_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bm9 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[Heat Shock | *[[Heat Shock Protein structures|Heat Shock Protein structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 34: | Line 28: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arndt | [[Category: Large Structures]] | ||
[[Category: Boschelli | [[Category: Arndt K]] | ||
[[Category: Chopra | [[Category: Boschelli F]] | ||
[[Category: Ellingboe | [[Category: Chopra R]] | ||
[[Category: Golas | [[Category: Ellingboe J]] | ||
[[Category: Gopalsamy | [[Category: Golas J]] | ||
[[Category: Jacob | [[Category: Gopalsamy A]] | ||
[[Category: Johnson | [[Category: Jacob J]] | ||
[[Category: Lee | [[Category: Johnson J]] | ||
[[Category: Nilakantan | [[Category: Lee F]] | ||
[[Category: Peterson | [[Category: Nilakantan R]] | ||
[[Category: Shi | [[Category: Peterson R]] | ||
[[Category: Svenson | [[Category: Shi M]] | ||
[[Category: Tam | [[Category: Svenson K]] | ||
[[Category: Vogan | [[Category: Tam MS]] | ||
[[Category: Wen | [[Category: Vogan EM]] | ||
[[Category: Wen Y]] | |||
Latest revision as of 09:29, 21 February 2024
Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90
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