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==SOLUTION NMR STRUCTURE OF THE DWNN DOMAIN FROM HUMAN RBBP6==
 
<StructureSection load='2c7h' size='340' side='right' caption='[[2c7h]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
==Solution NMR structure of the DWNN domain from human RBBP6==
<StructureSection load='2c7h' size='340' side='right'caption='[[2c7h]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2c7h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C7H FirstGlance]. <br>
<table><tr><td colspan='2'>[[2c7h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C7H FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c7h RCSB], [http://www.ebi.ac.uk/pdbsum/2c7h PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<table>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7h OCA], [https://pdbe.org/2c7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c7h RCSB], [https://www.ebi.ac.uk/pdbsum/2c7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c7h ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RBBP6_HUMAN RBBP6_HUMAN] E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c7/2c7h_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c7/2c7h_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c7h ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2c7h" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Retinoblastoma-binding protein|Retinoblastoma-binding protein]]
*[[Retinoblastoma-binding protein 3D structures|Retinoblastoma-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ab, E.]]
[[Category: Large Structures]]
[[Category: Faro, A.]]
[[Category: Ab E]]
[[Category: Hoffmann, E.]]
[[Category: Faro A]]
[[Category: Lutya, P T.]]
[[Category: Hoffmann E]]
[[Category: Pugh, D J.R.]]
[[Category: Lutya PT]]
[[Category: Rees, D J.G.]]
[[Category: Pugh DJR]]
[[Category: Mrna processing]]
[[Category: Rees DJG]]
[[Category: Oesophageal cancer]]
[[Category: P53-associated]]
[[Category: Rbbp6]]
[[Category: Splicing-associated]]
[[Category: Ubiquitin-like protein]]
Retrieved from "https://proteopedia.org/2c7h"