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==Crystal structure of the actin-binding domain of human alpha-actinin 1 at 1.8 Angstrom resolution==
==Crystal structure of the actin-binding domain of human alpha-actinin 1 at 1.8 Angstrom resolution==
<StructureSection load='2eyn' size='340' side='right' caption='[[2eyn]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='2eyn' size='340' side='right'caption='[[2eyn]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2eyn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EYN FirstGlance]. <br>
<table><tr><td colspan='2'>[[2eyn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EYN FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2eyi|2eyi]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACTN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eyn OCA], [https://pdbe.org/2eyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eyn RCSB], [https://www.ebi.ac.uk/pdbsum/2eyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eyn ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eyn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eyn RCSB], [http://www.ebi.ac.uk/pdbsum/2eyn PDBsum]</span></td></tr>
</table>
<table>
== Function ==
[https://www.uniprot.org/uniprot/ACTN1_HUMAN ACTN1_HUMAN] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ey/2eyn_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ey/2eyn_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eyn ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2eyn" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Actinin|Actinin]]
*[[Actinin 3D structures|Actinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Borrego-Diaz, E.]]
[[Category: Large Structures]]
[[Category: Dominguez, R.]]
[[Category: Borrego-Diaz E]]
[[Category: Ferron, F.]]
[[Category: Dominguez R]]
[[Category: Kerff, F.]]
[[Category: Ferron F]]
[[Category: Lee, S H.]]
[[Category: Kerff F]]
[[Category: Li, Y.]]
[[Category: Lee SH]]
[[Category: Actin-binding]]
[[Category: Li Y]]
[[Category: Actin-bundling]]
[[Category: Actin-crosslinking]]
[[Category: Calponin homology domain]]
[[Category: Ch domain]]
[[Category: Structural protein]]
Retrieved from "https://proteopedia.org/2eyn"