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==CRYSTAL STRUCTURE OF PANTOTHENATE KINASE FROM LEGIONELLA PNEUMOPHILA==
==CRYSTAL STRUCTURE OF PANTOTHENATE KINASE FROM LEGIONELLA PNEUMOPHILA==
<StructureSection load='3djc' size='340' side='right' caption='[[3djc]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3djc' size='340' side='right'caption='[[3djc]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3djc]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._philadelphia_1 Legionella pneumophila subsp. pneumophila str. philadelphia 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DJC FirstGlance]. <br>
<table><tr><td colspan='2'>[[3djc]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._Philadelphia_1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DJC FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">coaX, lpg0911 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 Legionella pneumophila subsp. pneumophila str. Philadelphia 1])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3djc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3djc OCA], [https://pdbe.org/3djc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3djc RCSB], [https://www.ebi.ac.uk/pdbsum/3djc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3djc ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/3djc TOPSAN]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3djc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3djc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3djc RCSB], [http://www.ebi.ac.uk/pdbsum/3djc PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/3djc TOPSAN]</span></td></tr>
</table>
<table>
== Function ==
[https://www.uniprot.org/uniprot/COAX_LEGPH COAX_LEGPH] Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dj/3djc_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dj/3djc_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3djc ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Pantothenate kinase|Pantothenate kinase]]
*[[Pantothenate kinase 3D structures|Pantothenate kinase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Legionella pneumophila subsp. pneumophila str. philadelphia 1]]
[[Category: Large Structures]]
[[Category: Pantothenate kinase]]
[[Category: Legionella pneumophila subsp. pneumophila str. Philadelphia 1]]
[[Category: Almo, S C.]]
[[Category: Almo SC]]
[[Category: Bonanno, J B.]]
[[Category: Bonanno JB]]
[[Category: Burley, S K.]]
[[Category: Burley SK]]
[[Category: Dickey, M.]]
[[Category: Dickey M]]
[[Category: Koss, J.]]
[[Category: Koss J]]
[[Category: Logan, C.]]
[[Category: Logan C]]
[[Category: Maletic, M.]]
[[Category: Maletic M]]
[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
[[Category: Patskovsky Y]]
[[Category: Patskovsky, Y.]]
[[Category: Romero R]]
[[Category: Romero, R.]]
[[Category: Sauder JM]]
[[Category: Sauder, J M.]]
[[Category: Wasserman S]]
[[Category: Wasserman, S.]]
[[Category: Atp-binding]]
[[Category: Coenzyme a biosynthesis]]
[[Category: Kinase]]
[[Category: Metal-binding]]
[[Category: New york sgx research center for structural genomic]]
[[Category: New york structural genomix research consortium]]
[[Category: Nucleotide-binding]]
[[Category: Nysgxrc]]
[[Category: Pantothenate kinase]]
[[Category: Protein structure initiative]]
[[Category: Psi-2]]
[[Category: Putative transferase]]
[[Category: Structural genomic]]
[[Category: Transferase]]

Latest revision as of 09:41, 21 February 2024

CRYSTAL STRUCTURE OF PANTOTHENATE KINASE FROM LEGIONELLA PNEUMOPHILA

3djc, resolution 2.40Å

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