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==Crystal structure of a branched chain amino acid ABC transporter from Thermus thermophilus with bound valine==
==Crystal structure of a branched chain amino acid ABC transporter from Thermus thermophilus with bound valine==
<StructureSection load='3lkb' size='340' side='right' caption='[[3lkb]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3lkb' size='340' side='right'caption='[[3lkb]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3lkb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LKB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LKB FirstGlance]. <br>
<table><tr><td colspan='2'>[[3lkb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LKB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LKB FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=VAL:VALINE'>VAL</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TTHA0451 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=VAL:VALINE'>VAL</scene></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lkb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lkb RCSB], [http://www.ebi.ac.uk/pdbsum/3lkb PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lkb OCA], [https://pdbe.org/3lkb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lkb RCSB], [https://www.ebi.ac.uk/pdbsum/3lkb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lkb ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q5SL42_THET8 Q5SL42_THET8]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lk/3lkb_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lk/3lkb_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lkb ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>


==See Also==
==See Also==
*[[ABC transporter|ABC transporter]]
*[[ABC transporter 3D structures|ABC transporter 3D structures]]
*[[MDM2|MDM2]]
*[[MDM2 3D structures|MDM2 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Thermus thermophilus]]
[[Category: Large Structures]]
[[Category: Agarwal, R.]]
[[Category: Thermus thermophilus HB8]]
[[Category: Burley, S K.]]
[[Category: Agarwal R]]
[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
[[Category: Burley SK]]
[[Category: Swaminathan, S.]]
[[Category: Swaminathan S]]
[[Category: 11235g]]
[[Category: Abc transporter]]
[[Category: Branched amino acid]]
[[Category: New york sgx research center for structural genomic]]
[[Category: Nysgxrc]]
[[Category: Protein structure initiative]]
[[Category: Psi-ii]]
[[Category: Structural genomic]]
[[Category: Transport protein]]

Latest revision as of 10:21, 21 February 2024

Crystal structure of a branched chain amino acid ABC transporter from Thermus thermophilus with bound valine

3lkb, resolution 2.40Å

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