3jzi: Difference between revisions
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==Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series== | ==Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series== | ||
<StructureSection load='3jzi' size='340' side='right' caption='[[3jzi]], [[Resolution|resolution]] 2.31Å' scene=''> | <StructureSection load='3jzi' size='340' side='right'caption='[[3jzi]], [[Resolution|resolution]] 2.31Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3jzi]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3jzi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JZI FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JZL:7-AMINO-2-[(2-CHLOROBENZYL)AMINO]-1-{[(1S,2S)-2-HYDROXYCYCLOHEPTYL]METHYL}-1H-BENZIMIDAZOLE-5-CARBOXAMIDE'>JZL</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JZL:7-AMINO-2-[(2-CHLOROBENZYL)AMINO]-1-{[(1S,2S)-2-HYDROXYCYCLOHEPTYL]METHYL}-1H-BENZIMIDAZOLE-5-CARBOXAMIDE'>JZL</scene></td></tr> | |||
<tr | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzi OCA], [https://pdbe.org/3jzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jzi RCSB], [https://www.ebi.ac.uk/pdbsum/3jzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jzi ProSAT]</span></td></tr> | ||
</table> | |||
<table> | == Function == | ||
[https://www.uniprot.org/uniprot/ACCC_ECOLI ACCC_ECOLI] This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/3jzi_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/3jzi_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jzi ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
| Line 26: | Line 28: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3jzi" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[ | *[[Acetyl-CoA carboxylase 3D structures|Acetyl-CoA carboxylase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli K-12]] | ||
[[Category: Black | [[Category: Large Structures]] | ||
[[Category: Cheng | [[Category: Black T]] | ||
[[Category: Kawahata | [[Category: Cheng C]] | ||
[[Category: Mann | [[Category: Kawahata N]] | ||
[[Category: Orth | [[Category: Mann P]] | ||
[[Category: Shipps | [[Category: Orth P]] | ||
[[Category: Soriano | [[Category: Shipps GW]] | ||
[[Category: Soucy | [[Category: Soriano A]] | ||
[[Category: Sun | [[Category: Soucy K]] | ||
[[Category: Xiao | [[Category: Sun B]] | ||
[[Category: Yang | [[Category: Xiao L]] | ||
[[Category: Yang Z]] | |||
