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==SOLUTION STRUCTURE OF ROBUSTOXIN, THE LETHAL NEUROTOXIN FROM THE FUNNEL WEB SPIDER ATRAX ROBUSTUS, NMR, 20 STRUCTURES==
==SOLUTION STRUCTURE OF ROBUSTOXIN, THE LETHAL NEUROTOXIN FROM THE FUNNEL WEB SPIDER ATRAX ROBUSTUS, NMR, 20 STRUCTURES==
<StructureSection load='1qdp' size='340' side='right' caption='[[1qdp]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1qdp' size='340' side='right'caption='[[1qdp]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1qdp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atrax_robustus Atrax robustus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QDP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QDP FirstGlance]. <br>
<table><tr><td colspan='2'>[[1qdp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atrax_robustus Atrax robustus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QDP FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qdp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qdp RCSB], [http://www.ebi.ac.uk/pdbsum/1qdp PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<table>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qdp OCA], [https://pdbe.org/1qdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qdp RCSB], [https://www.ebi.ac.uk/pdbsum/1qdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qdp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TXDT1_ATRRO TXDT1_ATRRO] Inhibits tetrodotoxin-sensitive voltage-gated sodium channels (Nav) by binding to site 3. It slows the inactivation, causes a prolongation of action potential duration resulting in repetitive firing in autonomic and motor nerve fibers. Does not depolarize the resting potential. Does not affect tetrodotoxin-resistant sodium channels. This lethal neurotoxin is active on both insect and mammalian voltage-gated sodium channels.<ref>PMID:2728033</ref> <ref>PMID:14596608</ref> <ref>PMID:9845331</ref> <ref>PMID:9560455</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qd/1qdp_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qd/1qdp_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qdp ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 1qdp" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Atrax robustus]]
[[Category: Atrax robustus]]
[[Category: Alewood, D.]]
[[Category: Large Structures]]
[[Category: Alewood, P F.]]
[[Category: Alewood D]]
[[Category: Norton, R S.]]
[[Category: Alewood PF]]
[[Category: Pallaghy, P K.]]
[[Category: Norton RS]]
[[Category: Atrax robustus]]
[[Category: Pallaghy PK]]
[[Category: Cystine knot]]
[[Category: Funnel web spider]]
[[Category: Inhibitor cystine knot motif]]
[[Category: Neurotoxin]]
[[Category: Robustoxin]]
[[Category: Sodium channel modulator]]
[[Category: Venom]]
Retrieved from "https://proteopedia.org/1qdp"