2i1y: Difference between revisions
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==Crystal structure of the phosphatase domain of human PTP IA-2== | ==Crystal structure of the phosphatase domain of human PTP IA-2== | ||
<StructureSection load='2i1y' size='340' side='right' caption='[[2i1y]], [[Resolution|resolution]] 2.23Å' scene=''> | <StructureSection load='2i1y' size='340' side='right'caption='[[2i1y]], [[Resolution|resolution]] 2.23Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2i1y]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2i1y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I1Y FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr><td class="sblockLbl"><b> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1y OCA], [https://pdbe.org/2i1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i1y RCSB], [https://www.ebi.ac.uk/pdbsum/2i1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1y ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2i1y TOPSAN]</span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </table> | ||
<table> | == Function == | ||
[https://www.uniprot.org/uniprot/PTPRN_HUMAN PTPRN_HUMAN] Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.<ref>PMID:8144912</ref> <ref>PMID:8641276</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/2i1y_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/2i1y_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i1y ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2i1y" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Tyrosine phosphatase|Tyrosine phosphatase]] | *[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Almo | [[Category: Almo SC]] | ||
[[Category: Alvarado | [[Category: Alvarado J]] | ||
[[Category: Atwell | [[Category: Atwell S]] | ||
[[Category: Bain | [[Category: Bain KT]] | ||
[[Category: Burley | [[Category: Burley SK]] | ||
[[Category: Faber-Barata | [[Category: Faber-Barata J]] | ||
[[Category: Freeman | [[Category: Freeman M]] | ||
[[Category: Kearins | [[Category: Kearins MC]] | ||
[[Category: Koss | [[Category: Koss J]] | ||
[[Category: Maletic | [[Category: Maletic M]] | ||
[[Category: Ozyurt S]] | |||
[[Category: Ozyurt | [[Category: Patskovsky Y]] | ||
[[Category: Patskovsky | [[Category: Powell A]] | ||
[[Category: Powell | [[Category: Rooney I]] | ||
[[Category: Rooney | [[Category: Russell JC]] | ||
[[Category: Russell | [[Category: Smith D]] | ||
[[Category: Smith | [[Category: Thompson DA]] | ||
[[Category: Thompson | [[Category: Wasserman SR]] | ||
[[Category: Wasserman | |||
Latest revision as of 10:05, 30 August 2023
Crystal structure of the phosphatase domain of human PTP IA-2
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