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==STRUCTURAL CHARACTERISATION OF BTRK DECARBOXYLASE FROM BUTIROSIN BIOSYNTHESIS==
 
<StructureSection load='2j66' size='340' side='right' caption='[[2j66]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
==Structural characterisation of BtrK decarboxylase from butirosin biosynthesis==
<StructureSection load='2j66' size='340' side='right'caption='[[2j66]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2j66]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_circulans Bacillus circulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J66 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J66 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2j66]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Niallia_circulans Niallia circulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J66 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J66 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j66 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j66 RCSB], [http://www.ebi.ac.uk/pdbsum/2j66 PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
<table>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j66 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j66 OCA], [https://pdbe.org/2j66 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j66 RCSB], [https://www.ebi.ac.uk/pdbsum/2j66 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j66 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BTRK_NIACI BTRK_NIACI] Pyridoxal phosphate-dependent decarboxylase that catalyzes 1 step in the biosynthesis of the side chain of the aminoglycoside antibiotics in the biosynthetic pathway of butirosin. Able to decarboxylate L-ornithine, L-arginine, L-lysine, but not L-glutamate or any D-amino acids. Has low activity with substrates not bound to an acyl-carrier protein.<ref>PMID:15975512</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j6/2j66_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j6/2j66_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j66 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus circulans]]
[[Category: Large Structures]]
[[Category: Blundell, T L.]]
[[Category: Niallia circulans]]
[[Category: Chirgadze, D Y.]]
[[Category: Blundell TL]]
[[Category: Li, Y.]]
[[Category: Chirgadze DY]]
[[Category: Popovic, B.]]
[[Category: Li Y]]
[[Category: Spencer, J B.]]
[[Category: Popovic B]]
[[Category: Ahba biosynthesis]]
[[Category: Spencer JB]]
[[Category: Butirosin]]
[[Category: Decarboxylase]]
[[Category: Lyase]]
Retrieved from "https://proteopedia.org/2j66"