1i6x: Difference between revisions

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[[Image:1i6x.jpg|left|200px]]


{{Structure
==STRUCTURE OF A STAR MUTANT CRP-CAMP AT 2.2 A==
|PDB= 1i6x |SIZE=350|CAPTION= <scene name='initialview01'>1i6x</scene>, resolution 2.20&Aring;
<StructureSection load='1i6x' size='340' side='right'caption='[[1i6x]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene> and <scene name='pdbligand=CMP:ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE'>CMP</scene>
<table><tr><td colspan='2'>[[1i6x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I6X FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i6x OCA], [https://pdbe.org/1i6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i6x RCSB], [https://www.ebi.ac.uk/pdbsum/1i6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i6x ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref>  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i6/1i6x_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i6x ConSurf].
<div style="clear:both"></div>


'''STRUCTURE OF A STAR MUTANT CRP-CAMP AT 2.2 A'''
==See Also==
 
*[[Catabolite gene activator protein 3D structures|Catabolite gene activator protein 3D structures]]
 
== References ==
==About this Structure==
<references/>
1I6X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I6X OCA].
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Fox, R O.]]
[[Category: Fox RO]]
[[Category: Lee, J C.]]
[[Category: Lee JC]]
[[Category: White, M A.]]
[[Category: White MA]]
[[Category: CMP]]
[[Category: TRS]]
[[Category: allostery]]
[[Category: camp receptor protein (crp)]]
[[Category: catabolite activator protein (cap)]]
[[Category: dna binding cyclic amp]]
[[Category: transcription regulation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:46:19 2008''
Retrieved from "https://proteopedia.org/1i6x"