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==Crystal structure of a Bowman-Birk inhibitor from Vigna unguiculata seeds==
==Crystal structure of a Bowman-Birk inhibitor from Vigna unguiculata seeds==
<StructureSection load='2r33' size='340' side='right' caption='[[2r33]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='2r33' size='340' side='right'caption='[[2r33]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2r33]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vigna_unguiculata Vigna unguiculata]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ot6 2ot6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R33 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R33 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2r33]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Vigna_unguiculata Vigna unguiculata]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ot6 2ot6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R33 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ot6|2ot6]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r33 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r33 RCSB], [http://www.ebi.ac.uk/pdbsum/2r33 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r33 OCA], [https://pdbe.org/2r33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r33 RCSB], [https://www.ebi.ac.uk/pdbsum/2r33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r33 ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q4VVG2_VIGUN Q4VVG2_VIGUN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r3/2r33_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r3/2r33_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r33 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Different protease inhibitors including Bowman-Birk type (BBI) have been reported from the seeds of Vigna unguiculata. Protease isoinhibitors of double-headed Bowman-Birk type from the seeds of Vigna unguiculata have been purified and characterized. The BBI from Vigna unguiculata (Vu-BBI) has been found to undergo self-association to form very stable dimers and more complex oligomers, by size-exclusion chromatography and SDS-PAGE in the presence of urea. Many BBIs have been reported to undergo self-association to form homodimers or more complex oligomers in solution. Only one dimeric crystal structure of a BBI (pea-BBI) is reported to date. We report the three-dimensional structure of a Vu-BBI determined at 2.5 A resolution. Although, the inhibitor has a monomer fold similar to that found in other known structures of Bowman-Birk protease inhibitors, its quaternary structure is different from that commonly observed in this family. The structural elements responsible for the stability of monomer molecule and dimeric association are discussed. The Vu-BBI may use dimeric or higher quaternary association to maintain the physiological state and to execute its biological function.


Bowman-Birk protease inhibitor from the seeds of Vigna unguiculata forms a highly stable dimeric structure.,Rao KN, Suresh CG Biochim Biophys Acta. 2007 Oct;1774(10):1264-73. Epub 2007 Aug 3. PMID:17869196<ref>PMID:17869196</ref>
==See Also==
 
*[[Trypsin inhibitor 3D structures|Trypsin inhibitor 3D structures]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Vigna unguiculata]]
[[Category: Vigna unguiculata]]
[[Category: Rao, K N.]]
[[Category: Rao KN]]
[[Category: Suresh, C G.]]
[[Category: Suresh CG]]
[[Category: Bowman-birk protease inhibitor]]
[[Category: Plant protein]]
[[Category: Plant-pi]]
[[Category: Protein-protein interaction]]
[[Category: Serine protease inhibitor]]
[[Category: Vigna unguiculata]]

Latest revision as of 06:32, 3 April 2024

Crystal structure of a Bowman-Birk inhibitor from Vigna unguiculata seeds

2r33, resolution 2.50Å

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