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==CRYSTAL STRUCTURE OF THE SYNTHETASE DOMAIN OF HUMAN CTP SYNTHETASE==
==CRYSTAL STRUCTURE OF THE SYNTHETASE DOMAIN OF HUMAN CTP SYNTHETASE==
<StructureSection load='2vo1' size='340' side='right' caption='[[2vo1]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='2vo1' size='340' side='right'caption='[[2vo1]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2vo1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2c5m 2c5m]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VO1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VO1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2vo1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2c5m 2c5m]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VO1 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2c5m|2c5m]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/CTP_synthase CTP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.2 6.3.4.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vo1 OCA], [https://pdbe.org/2vo1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vo1 RCSB], [https://www.ebi.ac.uk/pdbsum/2vo1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vo1 ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vo1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vo1 RCSB], [http://www.ebi.ac.uk/pdbsum/2vo1 PDBsum]</span></td></tr>
</table>
<table>
== Disease ==
[https://www.uniprot.org/uniprot/PYRG1_HUMAN PYRG1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. A unique and recessive G to C mutation probably affecting a splice donor site at the junction of intron 17-18 and exon 18 has been identified in all patients. It results in expression of an abnormal transcript lacking exon 18 and a complete loss of the expression of the protein.<ref>PMID:24870241</ref>
== Function ==
[https://www.uniprot.org/uniprot/PYRG1_HUMAN PYRG1_HUMAN] This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.<ref>PMID:16179339</ref> <ref>PMID:24870241</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/2vo1_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/2vo1_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vo1 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2vo1" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: CTP synthase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C.]]
[[Category: Large Structures]]
[[Category: Berg, S Van Den.]]
[[Category: Arrowsmith C]]
[[Category: Berglund, H.]]
[[Category: Berglund H]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Ehn, M.]]
[[Category: Ehn M]]
[[Category: Flodin, S.]]
[[Category: Flodin S]]
[[Category: Graslund, S.]]
[[Category: Graslund S]]
[[Category: Hallberg, B M.]]
[[Category: Hallberg BM]]
[[Category: Hammarstrom, M.]]
[[Category: Hammarstrom M]]
[[Category: Holmberg-Schiavone, L.]]
[[Category: Holmberg-Schiavone L]]
[[Category: Kotenyoa, T.]]
[[Category: Kotenyoa T]]
[[Category: Kursula, P.]]
[[Category: Kursula P]]
[[Category: Moche, M.]]
[[Category: Moche M]]
[[Category: Nilsson-Ehle, P.]]
[[Category: Nilsson-Ehle P]]
[[Category: Nordlund, P.]]
[[Category: Nordlund P]]
[[Category: Ogg, D.]]
[[Category: Ogg D]]
[[Category: Persson, C.]]
[[Category: Persson C]]
[[Category: Sagemark, J.]]
[[Category: Sagemark J]]
[[Category: Schuler, H.]]
[[Category: Schuler H]]
[[Category: Stenmark, P.]]
[[Category: Stenmark P]]
[[Category: Sundstrom, M.]]
[[Category: Sundstrom M]]
[[Category: Thorsell, A G.]]
[[Category: Thorsell AG]]
[[Category: Weigelt, J.]]
[[Category: Van Den Berg S]]
[[Category: Amidotransferase]]
[[Category: Weigelt J]]
[[Category: Ctp]]
[[Category: Ctp synthase]]
[[Category: Ctp synthetase]]
[[Category: Ctp]]
[[Category: Cytidine 5-prime triphosphate synthetase]]
[[Category: Glutamine]]
[[Category: Glutamine amidotransferase]]
[[Category: Ligase]]
[[Category: Phosphoprotein]]
[[Category: Phosphorylation]]
[[Category: Pyrimidine biosynthesis]]
[[Category: Utp]]
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