2mv4: Difference between revisions
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The | ==Solution structure of myristoylated Y28F/Y67F mutant of the Mason-Pfizer monkey virus matrix protein== | ||
<StructureSection load='2mv4' size='340' side='right'caption='[[2mv4]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2mv4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mason-Pfizer_monkey_virus Mason-Pfizer monkey virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MV4 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mv4 OCA], [https://pdbe.org/2mv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mv4 RCSB], [https://www.ebi.ac.uk/pdbsum/2mv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mv4 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GAG_MPMV GAG_MPMV] p10 is the matrix protein. P14 is the nucleocapsid protein. p27 is the capsid protein. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The matrix protein (MA) of the Mason-Pfizer monkey virus (M-PMV) plays a key role in the transport and budding of immature retroviral particles from the host cell. Natural N-terminal myristoylation of MA is essential for the targeting of the particles to the plasma membrane and participates in the interaction of MA with membranes phospholipids. The mutation Y28F/Y67F in MA reduces budding and thus causes the accumulation of viral particles under the cytoplasmic membrane. To investigate the impact of Y28F/Y67F mutation on the structure of MA, we prepared this protein in amount and quality suitable for NMR spectroscopy. We report backbone, side-chain and myristoyl residue assignments of the Y28F/Y67F mutant of the M-PMV matrix protein, which will be used to study the interaction with membrane phospholipids and to determine the structure of the mutant matrix protein. | |||
Resonance assignments of the myristoylated Y28F/Y67F mutant of the Mason-Pfizer monkey virus matrix protein.,Dolezal M, Hrabal R, Ruml T, Rumlova M Biomol NMR Assign. 2015 Mar 15. PMID:25773138<ref>PMID:25773138</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2mv4" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mason-Pfizer monkey virus]] | |||
[[Category: Dolezal M]] | |||
[[Category: Hrabal R]] | |||
Latest revision as of 09:58, 21 December 2022
Solution structure of myristoylated Y28F/Y67F mutant of the Mason-Pfizer monkey virus matrix protein
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