4re8: Difference between revisions
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New page: '''Unreleased structure''' The entry 4re8 is ON HOLD Authors: Li, F.W., Cai, Q.X., Li, A.Z., Tian, X.Y., Weijia, W., Yuan, W., Hou, P.P., Wu, Q., Lin, T.W. Description: Crystal Structu... |
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==Crystal Structure of TR3 LBD in complex with Molecule 5== | |||
<StructureSection load='4re8' size='340' side='right'caption='[[4re8]], [[Resolution|resolution]] 2.16Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4re8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RE8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RE8 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3MJ:1-(3,4,5-TRIHYDROXYPHENYL)DODECAN-1-ONE'>3MJ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4re8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4re8 OCA], [https://pdbe.org/4re8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4re8 RCSB], [https://www.ebi.ac.uk/pdbsum/4re8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4re8 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Cai QX]] | |||
[[Category: Hou PP]] | |||
[[Category: Li AZ]] | |||
[[Category: Li FW]] | |||
[[Category: Lin TW]] | |||
[[Category: Tian XY]] | |||
[[Category: Weijia W]] | |||
[[Category: Wu Q]] | |||
[[Category: Yuan W]] | |||
