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==CRYSTAL STRUCTURE OF THE SPRPN10 VWA DOMAIN==
 
<StructureSection load='2x5n' size='340' side='right' caption='[[2x5n]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
==Crystal Structure of the SpRpn10 VWA domain==
<StructureSection load='2x5n' size='340' side='right'caption='[[2x5n]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2x5n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X5N FirstGlance]. <br>
<table><tr><td colspan='2'>[[2x5n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X5N FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x5n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x5n RCSB], [http://www.ebi.ac.uk/pdbsum/2x5n PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<table>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x5n OCA], [https://pdbe.org/2x5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x5n RCSB], [https://www.ebi.ac.uk/pdbsum/2x5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x5n ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RPN10_SCHPO RPN10_SCHPO] Protects ubiquitin chains against dissambly by deubiquitinating enzymes thereby promoting protein degradation.<ref>PMID:10809753</ref> <ref>PMID:12560082</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x5/2x5n_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x5/2x5n_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x5n ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2x5n" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Proteasome|Proteasome]]
*[[Proteasome 3D structures|Proteasome 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Boehringer, J.]]
[[Category: Boehringer J]]
[[Category: Brown, N R.]]
[[Category: Brown NR]]
[[Category: Endicott, J A.]]
[[Category: Endicott JA]]
[[Category: Gehring, K.]]
[[Category: Gehring K]]
[[Category: Gordon, C.]]
[[Category: Gordon C]]
[[Category: Lowe, E D.]]
[[Category: Lowe ED]]
[[Category: Noble, M E.M.]]
[[Category: Noble MEM]]
[[Category: Riedinger, C.]]
[[Category: Riedinger C]]
[[Category: Trempe, J F.]]
[[Category: Trempe J-F]]
[[Category: Nuclear protein]]
[[Category: Nucleus]]
[[Category: Proteasome]]
[[Category: Ubiquitin]]
Retrieved from "https://proteopedia.org/2x5n"