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==CRYSTAL STRUCTURE OF RAT ANGIOTENSINOGEN IN C2 SPACE GROUP==
 
<StructureSection load='2wxz' size='340' side='right' caption='[[2wxz]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
==Crystal structure of rat angiotensinogen in C2 space group==
<StructureSection load='2wxz' size='340' side='right'caption='[[2wxz]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2wxz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WXZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WXZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2wxz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WXZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WXZ FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2x0b|2x0b]], [[2wxy|2wxy]], [[2wy1|2wy1]], [[2wy0|2wy0]], [[2wxw|2wxw]], [[2wxx|2wxx]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wxz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wxz RCSB], [http://www.ebi.ac.uk/pdbsum/2wxz PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wxz OCA], [https://pdbe.org/2wxz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wxz RCSB], [https://www.ebi.ac.uk/pdbsum/2wxz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wxz ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ANGT_RAT ANGT_RAT] Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis (By similarity).<ref>PMID:18026570</ref>  Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone (By similarity).<ref>PMID:18026570</ref>  Angiotensin-3: stimulates aldosterone release (By similarity).<ref>PMID:18026570</ref>  Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects (By similarity). Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.<ref>PMID:18026570</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2wxz" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Hormone|Hormone]]
*[[Serpin 3D structures|Serpin 3D structures]]
*[[Serpin|Serpin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Carrell, R W.]]
[[Category: Carrell RW]]
[[Category: Read, R J.]]
[[Category: Read RJ]]
[[Category: Wei, Z.]]
[[Category: Wei Z]]
[[Category: Zhou, A.]]
[[Category: Zhou A]]
[[Category: Angiotensin]]
[[Category: Angiotensinogen]]
[[Category: Glycoprotein]]
[[Category: Hormone]]
[[Category: Hypertension]]
[[Category: Renin]]
[[Category: Vasoactive]]
[[Category: Vasoconstrictor]]
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