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==Crystal structure of human estrogen-related receptor gamma ligand binding domain complex with bisphenol Z==
==Crystal structure of human estrogen-related receptor gamma ligand binding domain complex with bisphenol Z==
<StructureSection load='2zkc' size='340' side='right' caption='[[2zkc]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='2zkc' size='340' side='right'caption='[[2zkc]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2zkc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZKC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZKC FirstGlance]. <br>
<table><tr><td colspan='2'>[[2zkc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZKC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZKC FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BPZ:4,4-CYCLOHEXANE-1,1-DIYLDIPHENOL'>BPZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2e2r|2e2r]], [[2zas|2zas]], [[2zbs|2zbs]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BPZ:4,4-CYCLOHEXANE-1,1-DIYLDIPHENOL'>BPZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zkc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zkc RCSB], [http://www.ebi.ac.uk/pdbsum/2zkc PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zkc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zkc OCA], [https://pdbe.org/2zkc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zkc RCSB], [https://www.ebi.ac.uk/pdbsum/2zkc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zkc ProSAT]</span></td></tr>
<table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).<ref>PMID:19067653</ref> <ref>PMID:18063693</ref> <ref>PMID:11864604</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zk/2zkc_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zk/2zkc_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zkc ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Estrogen-related receptor|Estrogen-related receptor]]
*[[Estrogen-related receptor 3D structures|Estrogen-related receptor 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Kakuta, Y.]]
[[Category: Large Structures]]
[[Category: Matsushima, A.]]
[[Category: Kakuta Y]]
[[Category: Shimohigashi, Y.]]
[[Category: Matsushima A]]
[[Category: Teramoto, T.]]
[[Category: Shimohigashi Y]]
[[Category: Activator]]
[[Category: Teramoto T]]
[[Category: Bpa]]
[[Category: Dna-binding]]
[[Category: Err gamma]]
[[Category: Metal-binding]]
[[Category: Nuclear receptor]]
[[Category: Nucleus]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Zinc-finger]]
Retrieved from "https://proteopedia.org/2zkc"