2jfd: Difference between revisions
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==Structure of the MAT domain of human FAS== | ==Structure of the MAT domain of human FAS== | ||
<StructureSection load='2jfd' size='340' side='right' caption='[[2jfd]], [[Resolution|resolution]] 2.81Å' scene=''> | <StructureSection load='2jfd' size='340' side='right'caption='[[2jfd]], [[Resolution|resolution]] 2.81Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2jfd]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2jfd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JFD FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81Å</td></tr> | ||
<tr | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jfd OCA], [https://pdbe.org/2jfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jfd RCSB], [https://www.ebi.ac.uk/pdbsum/2jfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jfd ProSAT]</span></td></tr> | ||
</table> | |||
<table> | == Function == | ||
[https://www.uniprot.org/uniprot/FAS_HUMAN FAS_HUMAN] Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jf/2jfd_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jf/2jfd_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jfd ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2jfd" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Fatty acid synthase|Fatty acid synthase]] | *[[Fatty acid synthase 3D structures|Fatty acid synthase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Bunkoczi | [[Category: Bunkoczi G]] | ||
[[Category: Edwards | [[Category: Edwards A]] | ||
[[Category: Hozjan | [[Category: Hozjan V]] | ||
[[Category: Kavanagh | [[Category: Kavanagh K]] | ||
[[Category: Oppermann | [[Category: Oppermann U]] | ||
[[Category: Rojkova | [[Category: Rojkova A]] | ||
[[Category: Smith | [[Category: Smith S]] | ||
[[Category: Sundstrom | [[Category: Sundstrom M]] | ||
[[Category: Weigelt | [[Category: Weigelt J]] | ||
[[Category: Wu | [[Category: Wu X]] | ||
Latest revision as of 09:37, 9 May 2024
Structure of the MAT domain of human FAS
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