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==A MUTANT OF TRYPANOSOMA RANGELI SIALIDASE DISPLAYING TRANS-SIALIDASE ACTIVITY==
 
<StructureSection load='1wcs' size='340' side='right' caption='[[1wcs]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
==A mutant of Trypanosoma rangeli sialidase displaying trans-sialidase activity==
<StructureSection load='1wcs' size='340' side='right'caption='[[1wcs]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1wcs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_rangeli Trypanosoma rangeli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WCS FirstGlance]. <br>
<table><tr><td colspan='2'>[[1wcs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_rangeli Trypanosoma rangeli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WCS FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mz5|1mz5]], [[1mz6|1mz6]], [[1n1s|1n1s]], [[1n1t|1n1t]], [[1n1v|1n1v]], [[1n1y|1n1y]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wcs OCA], [https://pdbe.org/1wcs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wcs RCSB], [https://www.ebi.ac.uk/pdbsum/1wcs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wcs ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wcs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wcs RCSB], [http://www.ebi.ac.uk/pdbsum/1wcs PDBsum]</span></td></tr>
</table>
<table>
== Function ==
[https://www.uniprot.org/uniprot/O44049_TRYRA O44049_TRYRA]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wc/1wcs_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wc/1wcs_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wcs ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 1wcs" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Exo-alpha-sialidase]]
[[Category: Large Structures]]
[[Category: Trypanosoma rangeli]]
[[Category: Alzari, P M.]]
[[Category: Amaya, M F.]]
[[Category: Frasch, C.]]
[[Category: Nguyen, T.]]
[[Category: Paris, G.]]
[[Category: Ratier, L.]]
[[Category: Hydrolase]]
[[Category: Protein engineering]]
[[Category: Sialidase]]
[[Category: Trans-sialidase]]
[[Category: Trypanosoma cruzi]]
[[Category: Trypanosoma rangeli]]
[[Category: Trypanosoma rangeli]]
[[Category: Alzari PM]]
[[Category: Amaya MF]]
[[Category: Frasch C]]
[[Category: Nguyen T]]
[[Category: Paris G]]
[[Category: Ratier L]]
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