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==The crystal structure of the DUB domain of AMSH orthologue, Sst2 from S. pombe, in complex with lysine 63-linked diubiquitin==
==The crystal structure of the DUB domain of AMSH orthologue, Sst2 from S. pombe, in complex with lysine 63-linked diubiquitin==
<StructureSection load='4nql' size='340' side='right' caption='[[4nql]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4nql' size='340' side='right'caption='[[4nql]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4nql]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NQL FirstGlance]. <br>
<table><tr><td colspan='2'>[[4nql]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NQL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2znv|2znv]], [[3rzv|3rzv]], [[4msq|4msq]], [[4msm|4msm]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nql OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nql RCSB], [http://www.ebi.ac.uk/pdbsum/4nql PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nql OCA], [https://pdbe.org/4nql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nql RCSB], [https://www.ebi.ac.uk/pdbsum/4nql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nql ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SST2_SCHPO SST2_SCHPO] Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in the multivesicular body (MVB) sorting pathway. Required for ubiquitin-dependent sorting of proteins into the endosome and subsequent trafficking to the vacuole. May regulate MVB sorting through deubiquitination of ubiquitinated ESCRT proteins.<ref>PMID:17660439</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4nql" style="background-color:#fffaf0;"></div>
==See Also==
*[[3D structures of ubiquitin|3D structures of ubiquitin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Das, C.]]
[[Category: Large Structures]]
[[Category: Ronau, J A.]]
[[Category: Mus musculus]]
[[Category: Shrestha, R K.]]
[[Category: Schizosaccharomyces pombe 972h-]]
[[Category: Amsh]]
[[Category: Das C]]
[[Category: Cytosol]]
[[Category: Ronau JA]]
[[Category: Deubiquitinase]]
[[Category: Shrestha RK]]
[[Category: Endosome]]
[[Category: Heix-beta-helix sandwich]]
[[Category: Helix-beta-helix sandwich]]
[[Category: Hse1]]
[[Category: Hydrolase]]
[[Category: Hydrolase-protein binding complex]]
[[Category: Jamm domain]]
[[Category: K63-linked diubiquitin]]
[[Category: Metal binding]]
[[Category: Protein complex]]
[[Category: Ubiquitin]]
[[Category: Zinc metalloprotease]]
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