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==NMR SOLUTION STRUCTURE OF PHOSPHOLIPASE C EPSILON RA 1 DOMAIN==
 
<StructureSection load='2bye' size='340' side='right' caption='[[2bye]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
==NMR solution structure of phospholipase c epsilon RA 1 domain==
<StructureSection load='2bye' size='340' side='right'caption='[[2bye]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2bye]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BYE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BYE FirstGlance]. <br>
<table><tr><td colspan='2'>[[2bye]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BYE FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2byf|2byf]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bye OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bye RCSB], [http://www.ebi.ac.uk/pdbsum/2bye PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bye OCA], [https://pdbe.org/2bye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bye RCSB], [https://www.ebi.ac.uk/pdbsum/2bye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bye ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/PLCE1_HUMAN PLCE1_HUMAN] Familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis;Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/PLCE1_HUMAN PLCE1_HUMAN] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation.<ref>PMID:11022047</ref> <ref>PMID:11395506</ref> <ref>PMID:11715024</ref> <ref>PMID:11877431</ref> <ref>PMID:12721365</ref> <ref>PMID:16537651</ref> <ref>PMID:17086182</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 2bye" style="background-color:#fffaf0;"></div>
==See Also==
*[[Phospholipase C|Phospholipase C]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bunney, T D.]]
[[Category: Large Structures]]
[[Category: Driscoll, P C.]]
[[Category: Bunney TD]]
[[Category: Esposito, D.]]
[[Category: Driscoll PC]]
[[Category: Gandarillas, N L.]]
[[Category: Esposito D]]
[[Category: Gieschik, P.]]
[[Category: Gandarillas NL]]
[[Category: Harris, R.]]
[[Category: Gieschik P]]
[[Category: Josephs, M B.]]
[[Category: Harris R]]
[[Category: Katan, M.]]
[[Category: Josephs MB]]
[[Category: Paterson, H F.]]
[[Category: Katan M]]
[[Category: Pearl, L H.]]
[[Category: Paterson HF]]
[[Category: Rodrigues-Lima, F.]]
[[Category: Pearl LH]]
[[Category: Roe, S M.]]
[[Category: Rodrigues-Lima F]]
[[Category: Lipase]]
[[Category: Roe SM]]
[[Category: Phospholipase c epsilon]]
[[Category: Ras association domain]]
[[Category: Ubiquitin superfold]]
Retrieved from "https://proteopedia.org/2bye"