4wp0: Difference between revisions
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New page: '''Unreleased structure''' The entry 4wp0 is ON HOLD Authors: Nadvi, N.A., Salam, N.K., Park, J., Akladios, F.N., Kapoor, V., Collyer, C.A., Gorrell, M.D., Church, W.B. Description: Cr... |
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==Crystal structure of human kynurenine aminotransferase-I with a C-terminal V5-hexahistidine tag== | |||
<StructureSection load='4wp0' size='340' side='right'caption='[[4wp0]], [[Resolution|resolution]] 3.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4wp0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WP0 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wp0 OCA], [https://pdbe.org/4wp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wp0 RCSB], [https://www.ebi.ac.uk/pdbsum/4wp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wp0 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KAT1_HUMAN KAT1_HUMAN] Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.<ref>PMID:19338303</ref> | |||
==See Also== | |||
*[[Aminotransferase 3D structures|Aminotransferase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Akladios FN]] | |||
[[Category: Church WB]] | |||
[[Category: Collyer CA]] | |||
[[Category: Gorrell MD]] | |||
[[Category: Kapoor V]] | |||
[[Category: Nadvi NA]] | |||
[[Category: Park J]] | |||
[[Category: Salam NK]] | |||
Latest revision as of 07:34, 27 September 2023
Crystal structure of human kynurenine aminotransferase-I with a C-terminal V5-hexahistidine tag
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