2uw2: Difference between revisions
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== | ==Crystal structure of human ribonucleotide reductase subunit R2== | ||
<StructureSection load='2uw2' size='340' side='right'caption='[[2uw2]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2uw2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2iyh 2iyh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UW2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uw2 OCA], [https://pdbe.org/2uw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uw2 RCSB], [https://www.ebi.ac.uk/pdbsum/2uw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uw2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RIR2_HUMAN RIR2_HUMAN] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/2uw2_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uw2 ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arrowsmith C]] | |||
[[Category: Arrowsmith | [[Category: Berglund H]] | ||
[[Category: Busam R]] | |||
[[Category: Berglund | [[Category: Collins R]] | ||
[[Category: Busam | [[Category: Edwards A]] | ||
[[Category: Collins | [[Category: Ehn M]] | ||
[[Category: Edwards | [[Category: Flodin S]] | ||
[[Category: Ehn | [[Category: Flores A]] | ||
[[Category: Flodin | [[Category: Graslund S]] | ||
[[Category: Flores | [[Category: Hallberg BM]] | ||
[[Category: Graslund | [[Category: Hammarstrom M]] | ||
[[Category: Hallberg | [[Category: Hogbom M]] | ||
[[Category: Hammarstrom | [[Category: Holmberg Schiavone L]] | ||
[[Category: Hogbom | [[Category: Kotenyova T]] | ||
[[Category: Kotenyova | [[Category: Magnusdottir A]] | ||
[[Category: Magnusdottir | [[Category: Moche M]] | ||
[[Category: Moche | [[Category: Nilsson-Ehle P]] | ||
[[Category: Nilsson-Ehle | [[Category: Nordlund P]] | ||
[[Category: Nordlund | [[Category: Nyman T]] | ||
[[Category: Nyman | [[Category: Ogg D]] | ||
[[Category: Ogg | [[Category: Persson C]] | ||
[[Category: Persson | [[Category: Sagemark J]] | ||
[[Category: Sagemark | [[Category: Stenmark P]] | ||
[[Category: Sundstrom M]] | |||
[[Category: Stenmark | [[Category: Thorsell AG]] | ||
[[Category: Sundstrom | [[Category: Uppenberg J]] | ||
[[Category: Thorsell | [[Category: Van Den Berg S]] | ||
[[Category: Uppenberg | [[Category: Wallden K]] | ||
[[Category: | [[Category: Weigelt J]] | ||
[[Category: | [[Category: Welin M]] | ||
[[Category: | |||
[[Category: | |||
Latest revision as of 09:52, 9 May 2024
Crystal structure of human ribonucleotide reductase subunit R2
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Large Structures
- Arrowsmith C
- Berglund H
- Busam R
- Collins R
- Edwards A
- Ehn M
- Flodin S
- Flores A
- Graslund S
- Hallberg BM
- Hammarstrom M
- Hogbom M
- Holmberg Schiavone L
- Kotenyova T
- Magnusdottir A
- Moche M
- Nilsson-Ehle P
- Nordlund P
- Nyman T
- Ogg D
- Persson C
- Sagemark J
- Stenmark P
- Sundstrom M
- Thorsell AG
- Uppenberg J
- Van Den Berg S
- Wallden K
- Weigelt J
- Welin M
