4d3c: Difference between revisions
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New page: '''Unreleased structure''' The entry 4d3c is ON HOLD until Oct 21 2016 Authors: Kang, Y.J., Kim, K.L., Cho, H.S., Chung, J.H. Description: Crystal structure of the NK1 domain of HGF in... |
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==Crystal structure of the NK1 domain of HGF in complex with anti-HGF monoclonal antibody SFN68.== | |||
<StructureSection load='4d3c' size='340' side='right'caption='[[4d3c]], [[Resolution|resolution]] 2.62Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4d3c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D3C FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.62Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d3c OCA], [https://pdbe.org/4d3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d3c RCSB], [https://www.ebi.ac.uk/pdbsum/4d3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d3c ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN] Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39) [MIM:[https://omim.org/entry/608265 608265]. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:19576567</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN] Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.<ref>PMID:15167892</ref> <ref>PMID:20624990</ref> | |||
==See Also== | |||
*[[Hepatocyte growth factor|Hepatocyte growth factor]] | |||
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Oryctolagus cuniculus]] | |||
[[Category: Cho HS]] | |||
[[Category: Chung JH]] | |||
[[Category: Kang YJ]] | |||
[[Category: Kim KL]] | |||
Latest revision as of 12:19, 20 December 2023
Crystal structure of the NK1 domain of HGF in complex with anti-HGF monoclonal antibody SFN68.
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